In this article, based on the generalized Type-II progressive hybrid censoring sample from the Burr Type-XII distribution, maximum likelihood and Bayesian inference are discussed. Point and interval estimates of unknown parameters, reliability, and hazard functions are developed. We employed several loss functions, such as squared error, LINEX, and general entropy, as symmetric and asymmetric loss functions and various prior distributions as informative and non-informative priors for Bayesian inference of unknown parameters. Under a generalized Type-II progressive hybrid censoring sample, we also propose a Bayesian one-sample prediction for unobserved failures. We conduct simulation study using the MCMC algorithm for the Bayesian approach based on several prior distributions. Finally, we apply the results of the theoretical research to real data.