A pseudo-primitive word with respect to an antimorphic involution θ is a word which cannot be written as a catenation of occurrences of a strictly shorter word t and θ(t). Properties of pseudo-primitive words are investigated in this paper. These properties link pseudo-primitive words with essential notions in combinatorics on words such as primitive words, (pseudo)-palindromes, and (pseudo)-commutativity. Their applications include an improved solution to the extended Lyndon-Schützenberger equation u 1 u 2 · · · u ℓ = v 1 · · · vnw 1 · · · wm, where u 1 , . . . , u ℓ ∈ {u, θ(u)}, v 1 , . . . , vn ∈ {v, θ(v)}, and w 1 , . . . , wm ∈ {w, θ(w)} for some words u, v, w, integers ℓ, n, m ≥ 2, and an antimorphic involution θ. We prove that for ℓ ≥ 4, n, m ≥ 3, this equation implies that u, v, w can be expressed in terms of a common word t and its image θ(t). Moreover, several cases of this equation where ℓ = 3 are examined.