This paper reviews the association between electroencephalography (EEG) activity and driver fatigue. The current literature shows substantial evidence of changes in brain wave activity, such as simultaneous changes in slow-wave activity (e.g., delta and theta activity) as well as alpha activity during driver fatigue. It is apparent from the literature review that EEG is a promising neurophysiological indicator of driver fatigue and has the potential to be incorporated into the development of a fatigue countermeasure device. The findings from this review are discussed in the light of directions for future fatigue research studies.