Omics in the detection and identification of biosynthetic pathways related to mycotoxin synthesis

González-López, Nicolás Mateo; Huertas-Ortiz, Kevin Andrey; Leguizamon-Guerrero, John Emerson; Arias-Cortés, María Mercedes; Tere-Peña, Claudia Patricia; García‐Castañeda, Javier Eduardo; Rivera‐Monroy, Zuly Jenny

doi:10.1039/d1ay01017d

Cited by 6 publications

(1 citation statement)

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“…The comprehensive use of genomics, transcriptomics, proteomics, metabolomics, phenomics and synthetic biology techniques enables the analysis of biosynthetic pathways and key enzymes of complex natural products. Furthermore, the utilization of natural medicines as safe and efficacious drugs could also be promoted by multi-omics technologies and network pharmacology which elucidating the complex mechanism of natural medicines (Chen and Song, 2016;González-López et al, 2021;Pandita et al, 2021). It is also applied in bionic cultivation and synthetic biology of natural products to achieve scientific, standardized and sustainable development of natural products (Clarke and Kitney, 2020;Jamieson et al, 2021;Zhu et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Gao,

Song,

Chen

et al. 2024

Front. Pharmacol.

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Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia and inflammation underlies joint destruction. Delaying or even blocking synovial angiogenesis has emerged as an important target of RA treatment. Natural medicines has a long history of treating RA, and numerous reports have suggested that natural medicines have a strong inhibitory activity on synovial angiogenesis, thereby improving the progression of RA. Natural medicines could regulate the following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs pathway, NF-κB pathway, PPARγ pathway, JAK2/STAT3 pathway, etc., thereby inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, and total glucoside of Paeonia lactiflora Pall. Are currently the most representative of all natural products worthy of development and utilization. In this paper, the main factors affecting angiogenesis were discussed and different types of natural medicines that inhibit angiogenesis were systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming to provide new perspective and options for the management of RA by targeting angiogenesis.

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