Omic methodologies for assessing metal(-loid)s-host-microbiota interplay: A review

Ramírez-Acosta, Sara; Arias-Borrego, Ana; Navarro-Roldán, Francisco; Selma‐Royo, Marta; Calatayud, Marta; Collado, María Carmen; Huertas-Abril, Paula V.; Abril, Nieves; García-Barrera, Tamara

doi:10.1016/j.aca.2021.338620

Cited by 5 publications

(2 citation statements)

References 177 publications

(256 reference statements)

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“…A comprehensive review in an emerging human health related application area includes work covering the interplay between metal(loid)s and the host microbiota. 179 Significantly, it brings together the approaches of metabolomics, metallomics, metatranscriptomics and metaproteomics to investigating this relationship. The review, with 172 references, has a focus on dysbiosis (abdominal cramping, diarrhoea, and constipation) and the imbalance in gut bacteria related to metal(loid)s, in particular, the gut–brain axis.…”

Section: Biomolecular Speciation Analysismentioning

confidence: 99%

Atomic Spectrometry Update: review of advances in elemental speciation

Clough

Harrington

Hill

et al. 2022

J. Anal. At. Spectrom.

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Section: Biomolecular Speciation Analysismentioning

confidence: 99%

Atomic Spectrometry Update: review of advances in elemental speciation

Clough

Harrington

Hill

et al. 2022

J. Anal. At. Spectrom.

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“…They cover the study of “meta”genomes, regions of the ribosomal RNA genes, transcriptomes, proteomes or metabolomes, which are mixtures of genes, regions of genes (16S rRNA region), transcripts, proteins or metabolites from several organisms [10]. Meta‐omic methodologies pave the way to understand the impact of dietary Se in the microbiota and thus, the potential influence on other human niches and establishment of the specific axis: the “gut‐brain axis” (GBA), the “gut‐gonad crosstalk” or the “gut(enteromammary gland)‐brain axis” [11].…”

Section: Introductionmentioning

confidence: 99%

Omics insights into the responses to dietary selenium

Arias‐Borrego,

Callejón‐Leblic,

Collado

et al. 2023

Proteomics

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Selenium is a well‐known health‐relevant element related with cancer chemoprevention, neuroprotective roles, beneficial in diabetes, and in several infectious diseases, among others. It is naturally present in some foods, but deficiency in people led to the production of nutraceuticals, supplements, and functional food enriched in this element. There is a U‐shaped link between selenium levels and health and a narrow range between toxic and essential levels, and thus, supplementation should be performed carefully. Omics methodologies have become valuable approaches to delve into the responses of dietary selenium in mammals that allowed a deeper knowledge about the metabolism of this element as well as its biological role. In this review, we discuss omics approaches from the workflows to their applications that has been previously used to deep insight into the metabolism of dietary selenium. There is a special focus on selenoproteins, metabolomics responses in blood and tissues (e.g., brain, reproductive organs, etc.) as well as the impact on gut microbiota and its metabolites profile. Thus, we mainly reviewed heteroatom‐tagged proteomics, metallomics, metabolomics, and metataxonomics, usually combined with transcriptomics, genomics, and other molecular methods.

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