Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology

Tamhankar, Anand P.; Peters, Jeffrey H.; Portale, G; Hsieh, Chih‐Cheng; Hagen, Jeffrey A.; Bremner, Cedric G.; DeMeester, Tom R.

doi:10.1016/j.gassur.2004.08.001

Cited by 155 publications

(110 citation statements)

References 15 publications

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“…During follow-up after transplant, allograft function was decreased in patients with pretransplant GERD compared to those without GERD, such that by 18 months, FEV 1 was 70% of predicted in patients with GERD versus 83% among non-GERD patients. 5 Furthermore, survival early after transplant was significantly lower in the GERD patients. Testing for GERD with pH monitoring is also useful after transplant.…”

Section: Evaluation Of Patients With Esld Before and After Lung Transmentioning

confidence: 96%

“…4 Today, emphasis is also placed on the role of mixed gastroesophageal reflux 5 and on the transdiaphragmatic pressure gradient 6 as both have important therapeutic implications.…”

Section: Pathophysiology Of Gerd and Its Importance In Patients Withmentioning

confidence: 99%

“…For instance, Tamhankar et al showed that PPIs just change the pH of the gastric refluxate from acidic to weakly acidic or alkaline but do not change the occurrence and the number of reflux episodes. 5 The authors concluded, ''PPI treatment, while altering the pH of the gastric juice, does not correct the defects in the gastroesophageal barrier and consequently does not eliminate the presence and frequency of refluxed gastric contents.'' Hence, if one considers aspiration the central focus of lung deterioration before and after lung transplant, it is clear that treatment with PPI is not as effective as a fundoplication, which is able to stop any type of reflux events regardless of their pH.…”

Section: Pathophysiology Of Gerd and Its Importance In Patients Withmentioning

confidence: 99%

“…A study from the University of California San Francisco showed that for a 5-point increase in the body mass index, there was a 3-point rise in the DeMeester score. 5 This is particularly relevant in obese patients in whom there is an increased gradient because of a higher abdominal pressure and a more negative intrathoracic pressure. 7 …”

Section: Pathophysiology Of Gerd and Its Importance In Patients Withmentioning

confidence: 99%

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The Intersection of GERD, Aspiration, and Lung Transplantation

Patti

Vela

Odell

et al. 2016

Journal of Laparoendoscopic & Advanced Surgical Techniques

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Lung transplantation is a radical but life-saving treatment option for patients with end-stage lung diseases, such as idiopathic pulmonary fibrosis (IPF) and scleroderma. In light of the proposed association and controversy linking gastroesophageal reflux disease (GERD) to IPF and lung transplant outcome, the American Gastroenterological Association convened during the DDW in Washington in May 2015 a multidisciplinary group of experts in the field of GERD and lung transplantation to make considerations about the care of these patients based on available data and subsequent expert panel discussion at this symposium. The following topics were discussed: (1) pathophysiology of GERD-induced pulmonary symptoms, (2) GERD evaluation before and after lung transplantation, (3) outcome of lung transplantation for IPF and scleroderma, and (4) role of laparoscopic fundoplication before or after lung transplantation.

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Section: Evaluation Of Patients With Esld Before and After Lung Transmentioning

confidence: 96%

“…4 Today, emphasis is also placed on the role of mixed gastroesophageal reflux 5 and on the transdiaphragmatic pressure gradient 6 as both have important therapeutic implications.…”

Section: Pathophysiology Of Gerd and Its Importance In Patients Withmentioning

confidence: 99%

Section: Pathophysiology Of Gerd and Its Importance In Patients Withmentioning

confidence: 99%

Section: Pathophysiology Of Gerd and Its Importance In Patients Withmentioning

confidence: 99%

See 2 more Smart Citations

The Intersection of GERD, Aspiration, and Lung Transplantation

Patti

Vela

Odell

et al. 2016

Journal of Laparoendoscopic & Advanced Surgical Techniques

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“…This is consistent with other studies that investigated non-acidic reflux in patients who were non-responsive to PPI therapy. [23][24][25] Mainie et al 12 performed impedance pH monitoring in 168 PPI non-responsive GERD patients while on twice daily PPI. While 40% of symptoms were related to non-acid reflux, only 10% of symptoms were related to acid reflux.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease

Karyampudi

Ghoshal

Singh

et al. 2017

J Neurogastroenterol Motil

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Background/AimsThough nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting proton pump inhibitor, may cause NAB infrequently. Accordingly, we studied prospectively, (1) frequency and degree of esophageal acidification during NAB, and (2) frequency and severity of NAB while on ilaprazole versus omeprazole. MethodsFifty-eight consecutive patients with GERD on once daily ilaprazole, 10 mg (n = 28) or omeprazole, 20 mg (n = 30) for > one month underwent 24-hour impedance-pH monitoring prospectively. NAB was defined as intra-gastric pH < 4 for > one hour during night, and esophageal acidification as pH < 4 for any duration. Nocturnal symptoms (heartburn, regurgitation, and chest pain) were also recorded. Results Of ConclusionsThough NAB was common while patients were on a proton pump inhibitor, esophageal acidification was uncommon. Frequency and severity of NAB were comparable among patients on ilaprazole and omeprazole, except for the lesser number of NABs with ilaprazole.

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