Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer’s disease

Yan, Lilong; Xie, Youna; Satyanarayanan, Senthil Kumaran; Zeng, Haitao; Liu, Qiang; Huang, Miaodan; Ma, Yuemeng; Wan, Jian‐Bo; Yao, Xiaoli; Su, Kuan‐Pin; Su, Huanxing

doi:10.1016/j.bbi.2019.05.033

Cited by 40 publications

(20 citation statements)

References 56 publications

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“…Of related interest is the fact that fish oil feeding has been shown to support brain expression of LRP1 and enhance amyloid β export from the brain in AD model mice [201]. This might reflect inhibition of SREBP-2 expression, as fish oil has been shown to have this effect in other cellular contexts [202,203].…”

Section: Could Antioxidants Aid Expulsion Of Amyloid β From the Brain?mentioning

confidence: 99%

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

McCarty

DiNicolantonio

Lerner

2021

IJMS

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Oxidative stress and increased cytoplasmic calcium are key mediators of the detrimental effects on neuronal function and survival in Alzheimer’s disease (AD). Pathways whereby these perturbations arise, and then prevent dendritic spine formation, promote tau hyperphosphorylation, further amplify amyloid β generation, and induce neuronal apoptosis, are described. A comprehensive program of nutraceutical supplementation, comprised of the NADPH oxidase inhibitor phycocyanobilin, phase two inducers, the mitochondrial antioxidant astaxanthin, and the glutathione precursor N-acetylcysteine, may have important potential for antagonizing the toxic effects of amyloid β on neurons and thereby aiding prevention of AD. Moreover, nutraceutical antioxidant strategies may oppose the adverse impact of amyloid β oligomers on astrocyte clearance of glutamate, and on the ability of brain capillaries to export amyloid β monomers/oligomers from the brain. Antioxidants, docosahexaenoic acid (DHA), and vitamin D, have potential for suppressing microglial production of interleukin-1β, which potentiates the neurotoxicity of amyloid β. Epidemiology suggests that a health-promoting lifestyle, incorporating a prudent diet, regular vigorous exercise, and other feasible measures, can cut the high risk for AD among the elderly by up to 60%. Conceivably, complementing such lifestyle measures with long-term adherence to the sort of nutraceutical regimen outlined here may drive down risk for AD even further.

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Section: Could Antioxidants Aid Expulsion Of Amyloid β From the Brain?mentioning

confidence: 99%

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

McCarty

DiNicolantonio

Lerner

2021

IJMS

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“…To evaluate the effects of the dietary regime on the PUFA composition in the brain, the hippocampal and cortical tissue samples of APP/PS1 mice from fish oiland corn oil-treated groups (n = 3 per group) were processed for fatty acid analysis by gas chromatography-mass spectrometry (GC-MS) as described previously [33]. Quantifications were performed by an investigator who was blind to the animal grouping and carried out by normalizing individual peak areas as the percentage of total fatty acids.…”

Section: Fatty Acid Analysismentioning

confidence: 99%

Fish oil protects the blood–brain barrier integrity in a mouse model of Alzheimer’s disease

et al. 2020

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Background: Alzheimer's disease (AD) is ranked as the most prevalent neurodegenerative disease. However, the exact molecular mechanisms underlying pathophysiological alterations in AD remain unclear, especially at the prodromal stage. The decreased proteolytic degradation of Aβ, blood-brain barrier (BBB) disruption, and neuroinflammation are considered to play key roles in the course of AD. Methods: Male APPswe/PS1dE9 C57BL/6 J double-transgenic (APP/PS1) mice in the age range from 1 month to 6 months and age-matched wild type mice were used in this study, intending to investigate the expression profiles of Aβ-degrading enzymes for Aβ degradation activities and zonula occludens-1 (zo-1) for BBB integrity at the prodromal stage. Results: Our results showed that there were no significant genotype-related alterations in mRNA expression levels of 4 well-characterized Aβ-degrading enzymes in APP/PS1 mice within the ages of 6 months. Interestingly, a significant decrease in zo-1 expression was observed in APP/PS1 mice starting from the age of 5 months, suggesting that BBB disrupt occurs at an early stage. Moreover, treatment of fish oil (FO) for 4 weeks remarkably increased zo-1 expression and significantly inhibited the glial activation and NF-κB activation in APP/PS1 mice. Conclusion: The results of our study suggest that FO supplement could be a potential therapeutic early intervention for AD through protecting the BBB integrity and suppressing glial and NF-κB activation.

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“…The information provided was obtained based on scientific articles that proved the relationship of omega-3 to the reduction of total cholesterol and LDL (Olson & Aryana, 2017;Comunian & Favaro-Tindade, 2016;Let et al, 2007), prevention of diseases such as diabetes (Shilpa et al, 2020), Alzheimer (Yan et al, 2020;Belkouch et al, 2016), and neurodegenerative diseases (Kerdiles et al, 2017). In addition to having anti-inflammatory properties (Singer et al, 2008), contributing to cancer control (Abedi et al, 2020;Story, 2020) and contributing to athetic performance (Visconti et al, 2021).…”

Section: Hedonic Threshold Methodology -Open-label Trial On the Addition Of Omega-3 And Its Health Benefitsmentioning

confidence: 99%

Effect of a health claim on consumer acceptance of milk-based dessert containing omega-3

Madalão

Simiqueli

Filho

et al. 2021

RSD

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This study was to evaluate the influence of information on the addition of omega-3 and its health benefits in the acceptance of dairy dessert. The hedonic thresholds methodology was applied in two trials: blind and open-label. In the blind trial, no information was provided to consumers regarding the formulation of the flans. In the open-label trial, consumers received the information on the addition of omega-3 and its health benefits. The value of compromised acceptance threshold (CAT) was not influenced by the information on the addition of omega-3 and its health benefits. However, there was a high increase in the value of hedonic rejection threshold (HRT) when the consumers were informed of the benefits of omega-3, and it was possible to increase the addition of the compound in the flans by up to 21.03% without causing product rejection, confirming the positive effect of information on health benefits in accptance.

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Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer’s disease

Cited by 40 publications

References 56 publications

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

Fish oil protects the blood–brain barrier integrity in a mouse model of Alzheimer’s disease

Effect of a health claim on consumer acceptance of milk-based dessert containing omega-3

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