Omega-3 polyunsaturated fatty acids ameliorate the severity of ileitis in the senescence accelerated mice (SAM)P1/Yit mice model

Matsunaga, Hisayuki; Hokari, Ryota; Kurihara, Chie; Okada, Yoshikiyo; Takebayashi, Koichi; Okudaira, Keisuke; Watanabe, Chikako; Komoto, Shunsuke; Nakamura, Mitsuyasu; Tsuzuki, Yoshikazu; Kawaguchi, Atsushı; Nagao, Shigeaki; Miura, Soichiro

doi:10.1111/j.1365-2249.2009.04020.x

Cited by 35 publications

(21 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyunsaturated fatty acids (n-3 PUFA) enhance intestinal epithelial barrier function (57) and reportedly relocalize occludin and ZO-1 to lipid raft fractions (23). In vivo, n-3 PUFA supplementation has been shown to attenuate inflammation or promote remission in both murine (8,32) and human (55) IBD.…”

Section: Discussionmentioning

confidence: 99%

Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier

Bowie

Donatello

Lyes

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier

Bowie

Donatello

Lyes

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

“…In addition, a pilot study showed that the levels of the TFAs octadecenoate and hexadecenoate in subcutaneous adipose tissue were significantly higher in patients with Crohn's disease than in healthy individuals [28]. Numerous studies have reported that the composition of total fatty acids in the diet is an important factor influencing intestinal inflammation in IBD [4][5][6][29][30][31][32]. Our data suggest that patients with IBD should also be concerned with the proportion of the trans forms of fatty acids in their diet, because it is probably a significant risk factor for the progression or relapse of colitis.…”

Section: Discussionmentioning

confidence: 99%

Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization

Okada

Tsuzuki

Sato

et al. 2013

Clinical and Experimental Immunology

Self Cite

View full text Add to dashboard Cite

SummaryNumerous reports have shown that a diet containing large amounts of trans fatty acids (TFAs) is a major risk factor for metabolic disorders. Although recent studies have shown that TFAs promote intestinal inflammation, the underlying mechanisms are unknown. In this study, we examined the effects of dietary fat containing TFAs on dextran sodium sulphate (DSS)-induced colitis. C57 BL/6 mice were fed a diet containing 1·3% TFAs (mainly C16:1, C18:1, C18:2, C20:1, C20:2 and C22:1), and then colitis was induced with 1·5% DSS. Colonic damage was assessed, and the mRNA levels of proinflammatory cytokines and major regulators of T cell differentiation were measured. The TFA diet reduced survival and exacerbated histological damage in mice administered DSS compared with those fed a TFA-free diet. The TFA diet significantly elevated interleukin (IL)-6, IL-12p40, IL-23p19 and retinoic acid-related orphan receptor (ROR)γt mRNA levels in the colons of DSS-treated animals. Moreover, IL-17A mRNA levels were elevated significantly by the TFA diet, with or without DSS treatment. We also examined the expression of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and peritoneal macrophages. These cells were exposed to TFAs (linoelaidic acid or elaidic acid) with or without LPS and the mRNA levels of various cytokines were measured. IL-23p19 mRNA levels were increased significantly by TFAs in the absence of LPS. Cytokine expression was also higher in LPS-stimulated cells exposed to TFAs than in unexposed LPS-stimulated cells. Collectively, our results suggest that TFAs exacerbate colonic inflammation by promoting Th17 polarization and by up-regulating the expression of proinflammatory cytokines in the inflamed colonic mucosa.

show abstract

“…35 Both diet rich in fish oil and diet rich in perilla oil diet ameliorated ileitis significantly as assessed by histologically and macroscopically. 36 In both the omega-3 PUFA-rich diet groups, the number of infiltrating monocytes/macrophages and beta7-integrin positive lymphocytes were decreased significantly compared with those in the control diet group. Degree of expression of MAdCAM-1, which is a key adhesion molecule to be involved in CD, was decreased significantly by both treatments of diet.…”

Section: Dietary Omega-3 Pufa In Animal Model Of Small Intestinal Infmentioning

confidence: 93%

Effect of dietary fat on intestinal inflammatory diseases

Hokari

Matsunaga

Miura

2013

J of Gastro and Hepatol

View full text Add to dashboard Cite

Dietary fat has multiple roles on human health, and some dietary fat is used to treat organic diseases because of its anti-inflammatory effect. It is commonly accepted that omega-3 polyunsaturated fatty acid (PUFA) is beneficial on ischemic heart disease or rheumatic arthritis. On the contrary, effect of omega-3-PUFA on Crohn's disease remained controversial. That effect of omega-3 PUFA differs according to the location of inflamed intestine was hypothesized. To elucidate this hypothesis, to investigate the role of dietary fat on disease activity in different kind of murine models of intestinal inflammatory diseases was planned. The effect of omega-3 PUFA on small intestinal Crohn's disease model and large intestinal Crohn's disease model of mice. Chronic colitis model C57BL/6 mice received two cycles of dextran sodium sulfate solution treatment to induce chronic colitis. Feeding of omega-3 fat-rich diets exacerbated colitis with decrease in adiponectin expression. Chronic small intestinal inflammation model: SAMP1/Yit mice showed remarkable inflammation of the terminal ileum spontaneously. Feeding of omega-3 fat-rich diets for 16 weeks significantly ameliorated the inflammation of the terminal ileum. Enhanced infiltration of leukocytes and expression of mucosal addressin cell adhesion molecule-1 in intestinal mucosa was significantly decreased by omega-3 fat-rich diets treatment. Omega-3 PUFA has dual role, pro-/anti-inflammatory, on intestinal inflammatory diseases. The role of omega-3 fat and the potential for immunonutrition in inflammatory conditions of the gastrointestinal tract will be discussed.

show abstract

Omega-3 polyunsaturated fatty acids ameliorate the severity of ileitis in the senescence accelerated mice (SAM)P1/Yit mice model

Cited by 35 publications

References 41 publications

Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier

Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier

Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization

Effect of dietary fat on intestinal inflammatory diseases

Contact Info

Product

Resources

About