Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats

Abdel-Wahab, Basel A.; Shaikh, Ibrahim Ahmed; Khateeb, Masood Medleri; Habeeb, Shafiuddin M.

doi:10.1016/j.pbb.2015.05.020

Cited by 16 publications

(7 citation statements)

References 59 publications

(69 reference statements)

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“…In our study, reduced SOD, CAT, and GSH levels and increased MDA levels were detected after administration of LEV indicating that this drug resulted in the induction of oxidative stress in testicular tissue. Studies with opposing results have shown that administration of LEV had antioxidant effects in pathologies where oxidative stress is induced [53–57]. However, in another study, an increase in oxidative stress in the brain tissue of rats after administration of LEV was detected, similarly to that in our study [58].…”

Section: Discussionsupporting

confidence: 89%

Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress

et al. 2017

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Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of this drug on the male reproductive system, as it is commonly used in male patients of reproductive age. From this point of view, our aim was to evaluate the possible toxic effects of LEV on the male reproductive system. Therefore, LEV was administered to male rats orally at 50, 150, and 300 mg/kg for 70 consecutive days. At the end of this period, alterations to body and organ weights were calculated, and sperm concentration, motility, and morphology were investigated by a computer-assisted sperm analysis system. Sperm DNA damage was determined by comet assay and histopathological examination of the testes was carried out. Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were measured by ELISAs to determine the effects of hormonal status, while glutathione, superoxide dismutase, catalase, and malondialdehyde levels in the testes were measured by colorimetric assay kits to determine the role of oxidative status in potential toxicity. According to the results, sperm quality was decreased by LEV treatment in a dose-dependent manner. LEV induced significant DNA damage in the 150 and 300 mg/kg LEV-administered groups. Histopathology of the testes showed that LEV resulted in testicular injury in the 300 mg/kg LEV-administered group. Serum testosterone, FSH, and LH levels were significantly decreased in the 300 mg/kg LEV-administered group. Glutathione, superoxide dismutase, and catalase levels were significantly decreased in all experimental groups while malondialdehyde levels were significantly increased in 150 and 300 mg/kg LEV-administered groups. According to these results, it was determined that LEV administration decreased sperm quality and it was alleged that hormonal alteration and oxidative stress are potential contributors to reproductive toxicity.

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Section: Discussionsupporting

confidence: 89%

Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress

et al. 2017

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“…The key advantage of these two models is that they provide a persistent induction of epileptic-like conditions. Generally, repeated electrical stimulations of low intensity induce focal seizure discharge, leading to a highly reliable and progressive increase in epileptic response ( French et al, 1993 , Abdel-Wahab et al, 2015 , Lopes et al, 2015 ). Nevertheless, the employment of synthetic inducing agents, such as pentylenetetrazole, is equally effective for kindling induction in animal models ( Corda et al, 1990 ).…”

Section: Introductionmentioning

confidence: 99%

The antiepileptic potential of Vateria indica Linn in experimental animal models: Effect on brain GABA levels and molecular mechanisms

Alshabi

Shaikh

Asdaq³

2022

Saudi Journal of Biological Sciences

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“…Animal studies have demonstrated the beneficial effects of supplementation with omega-3 PUFAs on mice or rats with cognitive impairments due to different causes. Supplementation with ALA, or its derivative, DHA, in the diet of pregnant female rodents enhances the cognition of their offspring [ 58 , 120 , 150 , 192 , 193 , 194 , 195 , 196 , 197 ]. The pro-cognitive effects of these diets were associated with the enhancement of neurogenesis, dendritogenesis, and synaptogenesis, suggesting that they were mediated by an improvement in brain development.…”

Section: Fatty Acids and Cognitionmentioning

confidence: 99%

Fatty Acids: A Safe Tool for Improving Neurodevelopmental Alterations in Down Syndrome?

Martı́nez-Cué

Bartesaghi

2022

Nutrients

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The triplication of chromosome 21 causes Down syndrome (DS), a genetic disorder that is characterized by intellectual disability (ID). The causes of ID start in utero, leading to impairments in neurogenesis, and continue into infancy, leading to impairments in dendritogenesis, spinogenesis, and connectivity. These defects are associated with alterations in mitochondrial and metabolic functions and precocious aging, leading to the early development of Alzheimer’s disease. Intense efforts are currently underway, taking advantage of DS mouse models to discover pharmacotherapies for the neurodevelopmental and cognitive deficits of DS. Many treatments that proved effective in mouse models may raise safety concerns over human use, especially at early life stages. Accumulating evidence shows that fatty acids, which are nutrients present in normal diets, exert numerous positive effects on the brain. Here, we review (i) the knowledge obtained from animal models regarding the effects of fatty acids on the brain, by focusing on alterations that are particularly prominent in DS, and (ii) the progress recently made in a DS mouse model, suggesting that fatty acids may indeed represent a useful treatment for DS. This scenario should prompt the scientific community to further explore the potential benefit of fatty acids for people with DS.

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Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats

Cited by 16 publications

References 59 publications

Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress

Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress

The antiepileptic potential of Vateria indica Linn in experimental animal models: Effect on brain GABA levels and molecular mechanisms

Fatty Acids: A Safe Tool for Improving Neurodevelopmental Alterations in Down Syndrome?

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