Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?

Ross, Brian M.; Seguin, Jennifer; Sieswerda, Lee E.

doi:10.1186/1476-511x-6-21

Cited by 236 publications

(147 citation statements)

References 112 publications

(147 reference statements)

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“…Some transdiagnostic studies have aimed to compare fatty acid pattern alterations between psychiatric disorders (Hamazaki et al 2012;Hamazaki et al 2015), but evidence is still limited in that regard (Ross et al 2007). …”

Section: Associations Between Fatty Acid Alterations and Psychiatric mentioning

confidence: 99%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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Continuous research into the pathophysiology of psychiatric disorders, such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and schizophrenia, suggests an important role for metabolism. This narrative review will provide an upto-date summary of how metabolism is thought to be involved in the pathophysiology of these psychiatric disorders. We will focus on (I) the important role of fatty acids in these metabolic alterations, (II) whether fatty acid alterations represent epiphenomena or risk factors, and (III) similarities and dissociations in fatty acid alterations between different psychiatric disorders. (Historical) epidemiological evidence links fatty acid intake to psychiatric disorder prevalence, corroborated by altered fatty acid concentrations measured in psychiatric patients. These fatty acid alterations are connected with other concomitant pathophysiological mechanisms, including biological stress (hypothalamic-pituitary-adrenal (HPA)-axis and oxidative stress), inflammation, and brain network structure and function. Metabolomics and lipidomics studies are underway to more deeply investigate this complex network of associated neurometabolic alterations. Supplementation of fatty acids as disease-modifying nutraceuticals has clinical potential, particularly add-on eicosapentaenoic acid (EPA) in depressed patients with markers of increased inflammation. However, by interpreting the observed fatty acid alterations as partly (mal)adaptive phenomena, we attempt to nuance translational expectations and provide new clinical applications for these novel neurometabolic insights, e.g., to predict treatment response or depression recurrence. In conclusion, placing fatty acids in context can contribute to further understanding and optimized treatment of psychiatric disorders, in order to diminish their overwhelming burden of disease.

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Section: Associations Between Fatty Acid Alterations and Psychiatric mentioning

confidence: 99%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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show abstract

“…Fatty acids were also investigated in relation to affective disorders and affective disorders treatment (in particular, omega-3 fatty acids) [90]. Omega-3 fatty acids appear to cross the blood brain barrier easily and are incorporated into neuronal membranes.…”

Section: Affective Disordersmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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“…It is well known that n-3 PUFAs, particularly eicosapentaenoic acid EPA and docosahexaenoic acid DHA , are essential for the prevention and/or risk reduction of some diseases, such as arrhythmia 6 , atherosclerosis 7 , cardiovascular disease 8 , cancer 9 , inflammation 10 , and mental illness 11 . Although fish are currently the major source of and the diatoms Chaetoceros sp., Cylindrotheca closterium, Odontella aurita, and Phaeodactylum tricornutum 14 .…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid and Lipid Class Composition of the Microalga <i>Phaeodactylum tricorn</i><i>utum</i>

Yang

Hosokawa

et al. 2017

J. Oleo Sci.

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Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?

Cited by 236 publications

References 112 publications

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Application of fatty acid and lipid measurements in neuropsychiatry

Fatty Acid and Lipid Class Composition of the Microalga <i>Phaeodactylum tricorn</i><i>utum</i>

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