Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

Martínez-Fernández, Leyre; Laiglesia, Laura M.; Huerta, Ana; Martínéz, J. Alfredo; Moreno-Aliaga, María J.

doi:10.1016/j.prostaglandins.2015.07.003

Cited by 179 publications

(146 citation statements)

References 173 publications

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“…DHA could burst the citric acid cycle through the conversion of threonine and valine into succinyl-CoA [44], thereby enhancing the catabolism of sugar and fats and the production of energy. This could be an additional explanation for the beneficial effect of DHA in insulin resistance and diabetes [45], metabolic syndrome [46], and non-alcoholic fatty liver disease [47]. Aspartate is a non-essential amino acid in mammals, as it is produced from oxaloacetate by aspartate aminotransferase (AST).…”

Section: Discussionmentioning

confidence: 99%

Evidence of a DHA Signature in the Lipidome and Metabolome of Human Hepatocytes

Ghini

Nunzio

Tenori

et al. 2017

IJMS

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Cell supplementation with bioactive molecules often causes a perturbation in the whole intracellular environment. Omics techniques can be applied for the assessment of this perturbation. In this study, the overall effect of docosahexaenoic acid (DHA) supplementation on cultured human hepatocyte lipidome and metabolome has been investigated using nuclear magnetic resonance (NMR) in combination with traditional techniques. The effect of two additional bioactives sharing with DHA the lipid-lowering effect—propionic acid (PRO) and protocatechuic acid (PCA)—has also been evaluated in the context of possible synergism. NMR analysis of the cell lipid extracts showed that DHA supplementation, alone or in combination with PCA or PRO, strongly altered the cell lipid profile. The perfect discrimination between cells receiving DHA (alone or in combination) and the other cells reinforced the idea of a global rearrangement of the lipid environment induced by DHA. Notably, gas chromatography and fluorimetric analyses confirmed the strong discrimination obtained by NMR. The DHA signature was evidenced not only in the cell lipidome, but also in the metabolome. Results reported herein indicate that NMR, combined with other techniques, represents a fundamental approach to studying the effect of bioactive supplementation, particularly in the case of molecules with a broad spectrum of mechanisms of action.

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Section: Discussionmentioning

confidence: 99%

Evidence of a DHA Signature in the Lipidome and Metabolome of Human Hepatocytes

Ghini

Nunzio

Tenori

et al. 2017

IJMS

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“…For example, when mice or rats are fed a LA-enriched diet, the increase in fat mass can be prevented by LNA supplementation under isolipidic and isocaloric conditions (16,55,56). Using this strategy, we demonstrated herein that ω3 PUFA diet supplementation ameliorates brown adipocyte function in response to β-adrenergic stimulation, by promoting a more oxidative phenotype and to a lesser extent brite adipocyte recruitment.…”

Section: Downloaded Frommentioning

confidence: 91%

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Ghandour

Colson

Giroud

et al. 2018

Journal of Lipid Research

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“…The review was inspired by previous reviews to identify the beneficial effects of DHA in adipose tissue [27,28,29,30]. The literature search strategy focused on articles published in peer-reviewed and English-language journals between the years 1951 and 2016.…”

Section: Methodology Of Reference Selectionmentioning

confidence: 99%

Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans

Huang

Chien

Chen

et al. 2016

IJMS

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The incidence of obesity and its comorbidities, such as insulin resistance and type II diabetes, are increasing dramatically, perhaps caused by the change in the fatty acid composition of common human diets. Adipose tissue plays a role as the major energy reservoir in the body. An excess of adipose mass accumulation caused by chronic positive energy balance results in obesity. The n-3 polyunsaturated fatty acids (n-3 PUFA), DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) exert numerous beneficial effects to maintain physiological homeostasis. In the current review, the physiology of n-3 PUFA effects in the body is delineated from studies conducted in both human and animal experiments. Although mechanistic studies in human are limited, numerous studies conducted in animals and models in vitro provide potential molecular mechanisms of the effects of these fatty acids. Three aspects of n-3 PUFA in adipocyte regulation are discussed: (1) lipid metabolism, including adipocyte differentiation, lipolysis and lipogenesis; (2) energy expenditure, such as mitochondrial and peroxisomal fatty acid β-oxidation; and (3) inflammation, including adipokines and specialized pro-resolving lipid mediators. Additionally, the mechanisms by which n-3 PUFA regulate gene expression are highlighted. The beneficial effects of n-3 PUFA may help to reduce the incidence of obesity and its comorbidities.

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Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

Cited by 179 publications

References 173 publications

Evidence of a DHA Signature in the Lipidome and Metabolome of Human Hepatocytes

Evidence of a DHA Signature in the Lipidome and Metabolome of Human Hepatocytes

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans

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