Omega-3 Fatty Acids

Shahidi, Fereidoon; Ambigaipalan, Priyatharini

doi:10.1016/b978-0-08-100596-5.21753-8

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…Many authors reported the remarkable and significant bacteriolytic activity of palmitoleic acid-even at relatively low concentrationsagainst human pathogens and aquatic pathogenic bacteria as well as its ability to reduce the risk of certain heart diseases (Benkendorff et al, 2005;Plaza et al, 2009). Interestingly, among all these strains that are particularly rich in palmitoleic acid, only Lepto-CH appeared to produce omega-3 fatty acids (around 85% of total amount of palmitoleic acid) which are widely known for their protective role against diabetes, rheumatoid arthritis, rheumatism, skin diseases, digestive and metabolic diseases, neuro-cognitive disorders, and colorectal cancer (Shahidi and Ambigaipalan, 2018).…”

Section: Fatty Acid Compositionmentioning

confidence: 99%

Biochemical analysis of cyanobacterial strains isolated from different Tunisian inland waters: therapeutical and nutritional potential

Gharbi¹,

Fathalli²,

Fassatoui³

et al. 2019

Int. J. Bio. Chem. Sci

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The last decade period has been characterized by a remarkable increase in the need for food, bioenergy, and pharmaceutical compounds. Meanwhile, microalgae have been in the center of interest as a rich and sustainable source of highly valuable natural products and bioactive compounds. In this perspective, the present study aimed at investigating the biochemical composition of 10 cyanobacterial strains collected from several Tunisian inland waters, seeking to identify the possible use of cyanobacteria in nutraceuticals and pharmaceuticals industry, and for animal and human consumption. Ten local strains of cyanobacteria were isolated from several Tunisian inland waters and cultured in controlled laboratory conditions. Fatty Acid methyl esters were analyzed in each strain by Gas chromatography-Mass spectrometry (GC-MS) as well as total proteins, carbohydrates and different phycobiliproteins (phycocyanin, allophycocyanin and phycoerythrin). Results showed that Planktothrix agardhii, Leptolyngbya sp1., and Leptolyngbya sp2. contained 14 different fatty acids, among which oleic acid was the most abundant. These might be important in nutraceutical and agronomic sectors due to the potent antioxidant and larvicidal activities of oleic acid. Cylindrospermopsis raciborskii presents extraordinarily high levels of phycocyanin, making it an exceptional natural reservoir of effective and non-toxic drugs that are of particular interest against cancer and neurodegenerative diseases. Extracts from cyanobacterial strains represent a natural and available source of proteins, of highly valuable fatty acids, and especially of phycocyanin which is known by its extremely health beneficial properties. The nutritional and functional complements provided by these extracts can be used in the prevention of various diseases and also as effective and environmentally friendly insecticides.

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Section: Fatty Acid Compositionmentioning

confidence: 99%

Biochemical analysis of cyanobacterial strains isolated from different Tunisian inland waters: therapeutical and nutritional potential

Gharbi¹,

Fathalli²,

Fassatoui³

et al. 2019

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

show abstract

“…General essential omega-3 fatty acids beneficial for humans are linolenic acid (C18:3), stearidonic acid (C18:4), eicosapentaenoic acid (C20:5), docosapentaenoic acid (C22:5) and docosahexaenoic acid (C22:6) [1]. Recent studies revealed that the omega-3-fatty acids have the beneficial effects on Alzheimer disease and dementia-like age-related diseases, cardiovascular complications and fetal development [2]. Low level of omega-3 fatty acids will cause mental problems such as depression, dyspraxia and dyslexia, neurodegenerative diseases and heart problems [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies revealed that the omega-3-fatty acids have the beneficial effects on Alzheimer disease and dementia-like age-related diseases, cardiovascular complications and fetal development [2]. Low level of omega-3 fatty acids will cause mental problems such as depression, dyspraxia and dyslexia, neurodegenerative diseases and heart problems [2,3]. The main limitation of the production of omega-3 fatty acids is raw materials.…”

Section: Introductionmentioning

confidence: 99%

Plant hormone induced enrichment of Chlorella sp. omega-3 fatty acids

Sivaramakrishnan

Incharoensakdi

2020

Biotechnol Biofuels

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Background: Omega-3 fatty acids have various health benefits in combating against neurological problems, cancers, cardiac problems and hypertriglyceridemia. The main dietary omega-3 fatty acids are obtained from marine fish. Due to the pollution of marine environment, recently microalgae are considered as the promising source for the omega-3 fatty acid production. However, the demand and high production cost associated with microalgal biomass make it necessary to implement novel strategies in improving the biomass and omega-3 fatty acids from microalgae. Results: Four plant hormones zeatin, indole acetic acid (IAA), gibberellic acid (GBA) and abscisic acid (ABA) were investigated for their effect on the production of biomass and lipid in isolated Chlorella sp. The cells showed an increase of the biomass and lipid content after treatments with the plant hormones where the highest stimulatory effect was observed in ABA-treated cells. On the other hand, IAA showed the highest stimulatory effect on the omega-3 fatty acids content, eicosapentaenoic acid (EPA) (23.25%) and docosahexaenoic acid (DHA) (26.06%). On the other hand, cells treated with ABA had highest lipid content suitable for the biodiesel applications. The determination of ROS markers, antioxidant enzymes, and fatty acid biosynthesis genes after plant hormones treatment helped elucidate the mechanism underlying the improvement in biomass, lipid content and omega-3 fatty acids. All four plant hormones upregulated the fatty acid biosynthesis genes, whereas IAA particularly increased omega-3-fatty acids as a result of the upregulation of omega-3 fatty acid desaturase. Conclusions: The contents of omega-3 fatty acids, the clinically important compounds, were considerably improved in IAA-treated cells. The highest lipid content obtained from ABA-treated biomass can be used for biodiesel application according to its biodiesel properties. The EPA and DHA enriched ethyl esters are an approved form of omega-3 fatty acids by US Food and Drug Administration (FDA) which can be utilized as the therapeutic treatment for the severe hypertriglyceridemia.

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“…Recent studies reveal that maintaining low blood pressure even among individuals not diagnosed with hypertension is essential in reducing the incidences of cardiovascular diseases [39]. PUFAs regulate blood pressure through a number of different mechanisms, with the most common one is promoting the release of renin from the kidney [40]. Diets rich in omega-3 fatty acids have also been shown to suppress the activity of ACE (angiotensin converting enzyme) while at the same time suppressing the formation of angiotensin II which significantly improves the production of endothelial nitric oxide, a potent vasodilator while at the same time suppressing the action of Transforming Growth Factor-Beta [41,42].…”

Section: Impact Of ω-3 and ω-6 Pufas In Hypertensionmentioning

confidence: 99%

Omega 3 versus Omega 6 Polyunsaturated Fatty Acids in Cardio-Metabolic Health

Halim

2020

J Health Care and Research

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Background: Cardiometabolic diseases like type 2 diabetes, metabolic syndrome, heart failure, and other cardiovascular complications are the leading cause of mortality and morbidity across the globe. These conditions are directly attributed to modifiable behaviors such as sedentary activity, poor diet, excessive consumption of alcohol, or smoking. Efforts aimed towards their prevention and management are, therefore, not only essential in the accomplishment of the healthy populations but also for eliminating the associated cost and health burdens. Dietary change is an important approach to the promotion of cardiometabolic health. Omega 3 (C20–22 ω3) polyunsaturated fatty acids have pleiotropic effects on the functioning of cells, control inflammatory factors, and cellular events in vascular endothelial cells and cardiomyocytes. The hypolipemic, anti-arrhythmic, and anti-inflammatory properties of fatty acids offer cardioprotection. Government agencies and national heart associations recommend increased consumption of omega 3 polyunsaturated fatty acids (PUFA) supplements and fish to prevent cardiometabolic diseases. Purpose of the Study: The purpose of this study is to investigate the role played by ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic health. Methods: The research study searched databases such as MEDLINE®, Embase, PsycINFO, CINAHL® and the Cochrane Library for relevant research studies evaluating the function/benefits of polyunsaturated fatty acids particularly ω-3 and ω-6 polyunsaturated fatty acids in promoting cardiometabolic functions published between 2011 and 2020. A total of 77 research studies were identified and used in the meta-analysis. Results: Results from the meta-analysis indicated that polyunsaturated fatty acids lower the risk for cardiovascular disease by limiting inflammation of blood vessels, reducing thrombosis, increasing levels of high-density lipoproteins, reducing levels of low-density lipoproteins, and reducing risk factors associated with hypertension. Conclusion: Given the benefits of polyunsaturated fatty acids lower the risk for cardiovascular diseases indicted in the meta-analysis. Therefore, human diets must contain the required amounts of PUFA due to the associated benefits.

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Omega-3 Fatty Acids

Cited by 8 publications

References 35 publications

Biochemical analysis of cyanobacterial strains isolated from different Tunisian inland waters: therapeutical and nutritional potential

Biochemical analysis of cyanobacterial strains isolated from different Tunisian inland waters: therapeutical and nutritional potential

Plant hormone induced enrichment of Chlorella sp. omega-3 fatty acids

Omega 3 versus Omega 6 Polyunsaturated Fatty Acids in Cardio-Metabolic Health

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