Omega-3 Fatty Acid Supplementation is Associated With Oxidative Stress and Dyslipidemia, but Does not Contribute to Better Lipid and Oxidative Status on Hemodialysis Patients

Mattos, Andresa Marques de; Costa, José Abrão Cardeal da; Júnior, Alceu Afonso Jordão; Chiarello, Paula Garcia

doi:10.1053/j.jrn.2017.02.006

Cited by 18 publications

(17 citation statements)

References 26 publications

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“…161 In contrast with these results, another randomized, doubleblinded, controlled study showed no effect of EPA intake on OS and lipid profile of maintenance HD patients. 162 Moreover, a very recent meta-analysis that included 79 studies and 112 059 participants from the general population showed that intake of omega-3 polyunsaturated fatty acids had no beneficial effect on all-cause mortality, CV mortality, and CV events. 163 While results of studies often differ in dialysis patients, these outcome data suggest that treatment with omega-3 fatty acids for CV disease prevention cannot be justified in HD patients.…”

Section: Statins/omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

Liakopoulos

Roumeliotis

Zarogiannis

et al. 2018

Seminars in Dialysis

103

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Oxidative stress (OS) is the result of prooxidant molecules overwhelming the antioxidant defense mechanisms. Hemodialysis (HD) constitutes a state of elevated inflammation and OS, due to loss of antioxidants during dialysis and activation of white blood cells triggering production of reactive oxygen species. Dialysis vintage, dialysis methods, and type and condition of vascular access, biocompatibility of dialyzer membrane and dialysate, iron administration, and anemia all can play a role in aggravating OS, which in turn has been associated with increased morbidity and mortality. Oral or intravenous administration of antioxidants may detoxify the oxidative molecules and at least in part repair OS‐mediated tissue damage. Lifestyle interventions and optimization of a highly biocompatible HD procedure might ameliorate OS development in dialysis.

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Section: Statins/omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

Liakopoulos

Roumeliotis

Zarogiannis

et al. 2018

Seminars in Dialysis

103

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“…Although previous authors reported side effects of AAS use on physiological variables, the influence of this drug on oxidative stress responses is unclear. Oxidative stress is a condition in which the delicate balance between free radicals production and their subsequent amelioration via the antioxidant defense system becomes skewed in favor of free radical expression [17] , [18] , [19] . Since longitudinal administration of AAS provides dysfunction of mitochondrial respiratory chain complexes (major source of ROS) and mono-oxygenase systems [20] , it would be possible that these alterations were accompanied by an increased ROS generation resulting in oxidative stress and cell damage.…”

Section: Introductionmentioning

confidence: 99%

Use of anabolic androgenic steroids produces greater oxidative stress responses to resistance exercise in strength-trained men

2017

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“…In animal models of CKD, EPA and DHA supplementation reduce inflammation, fibrosis, and oxidative stress [ 234 , 235 , 236 ].…”

Section: Omega-3 Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease

Signorini

Granata

Lupo

et al. 2017

IJMS

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Oxidative stress is a well-described imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system of cells and tissues. The overproduction of free radicals damages all components of the cell (proteins, lipids, nucleic acids) and modifies their physiological functions. As widely described, this condition is a biochemical hallmark of chronic kidney disease (CKD) and may dramatically influence the progression of renal impairment and the onset/development of major systemic comorbidities including cardiovascular diseases. This state is exacerbated by exposure of the body to uremic toxins and dialysis, a treatment that, although necessary to ensure patients’ survival, exposes cells to non-physiological contact with extracorporeal circuits and membranes with consequent mitochondrial and anti-redox cellular system alterations. Therefore, it is undeniable that counteracting oxidative stress machinery is a major pharmacological target in medicine/nephrology. As a consequence, in recent years several new naturally occurring compounds, administered alone or integrated with classical therapies and an appropriate lifestyle, have been proposed as therapeutic tools for CKD patients. In this paper, we reviewed the recent literature regarding the “pioneering” in vivo testing of these agents and their inclusion in small clinical trials performed in patients affected by CKD.

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Omega-3 Fatty Acid Supplementation is Associated With Oxidative Stress and Dyslipidemia, but Does not Contribute to Better Lipid and Oxidative Status on Hemodialysis Patients

Cited by 18 publications

References 26 publications

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions

Use of anabolic androgenic steroids produces greater oxidative stress responses to resistance exercise in strength-trained men

Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease

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