Omega-3 Docosahexaenoic Acid Is a Mediator of Fate-Decision of Adult Neural Stem Cells

A, Lo Van; Hachem, Mayssa; Lagarde, Michel

doi:10.3390/ijms20174240

Cited by 18 publications

(13 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, we showed that the dietary imbalance in n-6/n-3 PUFA decreased the number of hippocampal neuroprogenitors. In agreement, docosahexaenoic acid (DHA), one of the derivates of n-3 PUFA, increases neuroprogenitors proliferation at low concentrations and promotes differentiation at higher ones [38]. Indeed, n-3 PUFA derivates promote neurogenesis in vitro without changing gliogenesis [39][40][41][42], which matches our observations in vivo (Figure 8).…”

Section: Discussionsupporting

confidence: 87%

Female Mice Susceptibility to the Dietary Omega-3/Omega-6 Fatty Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

Rodríguez-Iglesias¹,

Nadjar²,

Sierra³

et al. 2022

Preprint

View full text Add to dashboard Cite

Maternal intake of the polyunsaturated fatty acids omega-3 (n-3 PUFA) and omega-6 (n-6 PUFA) impacts hippocampal neurogenesis during development, an effect that may extend to adulthood by altering adult hippocampal neurogenesis (AHN). n-3 PUFA and n-6 PUFA are precursors of inflammatory regulators that potentially affect AHN and glia. Additionally, n-3 PUFA dietary supplementation may present a sexually dimorphic action in the brain. Therefore, we postulated that dietary n-6/n-3 PUFA balance shapes the adult DG in a sex-dependent manner influencing AHN and glia. We test our hypothesis by feeding adult female and male mice with n-3 PUFA balanced or deficient diets. To analyze the immunomodulatory potential of the diets, we injected mice with the bacterial endotoxin lipopolysaccharide (LPS). LPS reduced neuroblast number, and its effect was exacerbated by the n-3 PUFA deficient diet. The n-3 PUFA deficient diet reduced the DG volume, AHN, microglia number and surveilled volume. Diet effect on most mature neuroblasts was exclusively significant in female mice. Colocalization and multivariate analysis revealed an association between microglia and AHN, and the sexual dimorphic effect of diet. Our study reveals that female mice are more susceptible than males to the effect of dietary n-6/n-3 PUFA ratio on AHN and microglia.

show abstract

Section: Discussionsupporting

confidence: 87%

Female Mice Susceptibility to the Dietary Omega-3/Omega-6 Fatty Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

Rodríguez-Iglesias¹,

Nadjar²,

Sierra³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Importantly, in all cases in which it was assessed, the effects of HFD on stem cells appear to be reversible and could, therefore, potentially be corrected simply by changes in diet. Interestingly, while HFD seems to impair neurogenesis (Park H. R. et al, 2010;Ogrodnik et al, 2019), specific types of FAs, including omega-3 FAs appear to increase neurogenesis (Kang et al, 2014;Nascimento et al, 2016;Lo Van et al, 2019), suggesting that diet could be used to rescue neuronal loss in diseases and aging.…”

Section: Dietmentioning

confidence: 99%

Lipid Mediated Regulation of Adult Stem Cell Behavior

Clémot

Demarco

Jones

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self-renew or differentiate can be attributed to distinct metabolic states, and it is now becoming apparent that metabolism plays instructive roles in stem cell fate decisions. Lipids are an extremely vast class of biomolecules, with essential roles in energy homeostasis, membrane structure and signaling. Imbalances in lipid homeostasis can result in lipotoxicity, cell death and diseases, such as cardiovascular disease, insulin resistance and diabetes, autoimmune disorders and cancer. Therefore, understanding how lipid metabolism affects stem cell behavior offers promising perspectives for the development of novel approaches to control stem cell behavior either in vitro or in patients, by modulating lipid metabolic pathways pharmacologically or through diet. In this review, we will first address how recent progress in lipidomics has created new opportunities to uncover stem-cell specific lipidomes. In addition, genetic and/or pharmacological modulation of lipid metabolism have shown the involvement of specific pathways, such as fatty acid oxidation (FAO), in regulating adult stem cell behavior. We will describe and compare findings obtained in multiple stem cell models in order to provide an assessment on whether unique lipid metabolic pathways may commonly regulate stem cell behavior. We will then review characterized and potential molecular mechanisms through which lipids can affect stem cell-specific properties, including self-renewal, differentiation potential or interaction with the niche. Finally, we aim to summarize the current knowledge of how alterations in lipid homeostasis that occur as a consequence of changes in diet, aging or disease can impact stem cells and, consequently, tissue homeostasis and repair.

show abstract

“…First, we showed that the dietary imbalance in n-6/n-3 PUFA decreased the number of hippocampal neuroprogenitors. In agreement, docosahexaenoic acid (DHA), one of the derivates of n-3 PUFA, increases neuroprogenitor proliferation at low concentrations and promotes differentiation at higher ones [ 38 ]. Indeed, n-3 PUFA derivates promote neurogenesis in vitro without changing gliogenesis [ 39 , 40 , 41 , 42 ], which matches our observations in vivo ( Figure 8 ).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

Rodríguez-Iglesias

Nadjar

Sierra

et al. 2022

IJMS

View full text Add to dashboard Cite

Maternal intake of omega-3 (n-3 PUFAs) and omega-6 (n-6 PUFAs) polyunsaturated fatty acids impacts hippocampal neurogenesis during development, an effect that may extend to adulthood by altering adult hippocampal neurogenesis (AHN). The n-3 PUFAs and n-6 PUFAs are precursors of inflammatory regulators that potentially affect AHN and glia. Additionally, n-3 PUFA dietary supplementation may present a sexually dimorphic action in the brain. Therefore, we postulated that dietary n-6/n-3 PUFA balance shapes the adult DG in a sex-dependent manner influencing AHN and glia. We test our hypothesis by feeding adult female and male mice with n-3 PUFA balanced or deficient diets. To analyze the immunomodulatory potential of the diets, we injected mice with the bacterial endotoxin lipopolysaccharide (LPS). LPS reduced neuroblast number, and its effect was exacerbated by the n-3 PUFA-deficient diet. The n-3 PUFA-deficient diet reduced the DG volume, AHN, microglia number, and surveilled volume. The diet effect on most mature neuroblasts was exclusively significant in female mice. Colocalization and multivariate analysis revealed an association between microglia and AHN, as well as the sexual dimorphic effect of diet. Our study reveals that female mice are more susceptible than males to the effect of dietary n-6/n-3 PUFA ratio on AHN and microglia.

show abstract

Omega-3 Docosahexaenoic Acid Is a Mediator of Fate-Decision of Adult Neural Stem Cells

Cited by 18 publications

References 167 publications

Female Mice Susceptibility to the Dietary Omega-3/Omega-6 Fatty Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

Female Mice Susceptibility to the Dietary Omega-3/Omega-6 Fatty Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

Lipid Mediated Regulation of Adult Stem Cell Behavior

Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

Contact Info

Product

Resources

About