Omega-3 and vitamin E co-supplementation can improve antioxidant markers in obese/overweight women with polycystic ovary syndrome

Abstract

Abstract. Background: Polycystic ovary syndrome is one of the most important factors in female infertility. Oxidative stress is likely to contribute to increased insulin and androgen production in the ovaries, as well as probably impairing follicle production. Aims: This study aims to determine the complementary effects of omega-3 and vitamin E supplements on certain oxidative stress indices in obese and overweight women with polycystic ovary syndrome. Materials and Methods: This double-blind, randomized clinical trial was performed on polycystic ovary syndrome subjects with BMI > 25. Patients were randomly allocated into two groups to receive either 2 g of omega-3 plus 400 IU of vitamin E, or a placebo, for 8 weeks. At the beginning and the end of the study, total antioxidant capacity, glutathione levels, catalase activity, malondialdehyde concentrations, as well as dietary intake and physical activity were evaluated. Statistical analysis was performed using SPSS. Results: 32 patients in the intervention group and 30 patients in the placebo group completed the study. Co-supplementation of omega-3 and vitamin E significantly increased total antioxidant capacity (mg/dl) (1.15 ± 0.93 vs −0.6 ± 0.72; P < 0.001), catalase activity (IU/L) (1.19 ± 1.06 vs 0.12 ± 0.36; P < 0.001) and glutathione levels (μmol/L) (1.5 ± 1.06 vs 0.23 ± 1.43; P = 0.028). Additionally, a significant reduction of malondialdehyde levels (nmol/L) (−0.34 ± 0.32 vs 0.57 ± 2.20; P = 0.008) was observed, in comparison with placebo. Conclusion: Co-supplementation with omega-3 and vitamin E had beneficial effect on total antioxidant capacity, malondialdehyde concentrations, glutathione levels and catalase activity.

Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta‐analysis

“…2 . The GRADE framework 20 , 21 rated the strength of the evidence for all outcomes as moderate, except for BMI 16 , 23 , 24 , 26 , 27 , 31 – 33 and weight 16 , 23 , 24 , 26 , 27 , 32 , which were rated as high; progesterone 24 , LH 24 , 26 , 29 , 31 , FSH 24 , 26 , 29 , 31 , and CRP 32 , 34 , which were rated as low; and CAT 28 and PRL 29 , which were rated as very low strength (Table 2 supplementary) .

Figure 2 Assessment of the risk of bias in the included studies.

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Creatine Kinase Is a Marker of Metabolic Syndrome in Qatari Women With and Without Polycystic Ovarian Syndrome

“…CK is mainly derived from skeletal muscle and, in particular, the type II fibers that are associated with fatty acid storage in adipose tissue (20), due to their low glucose uptake and reduced mitochondrial oxidation (17, 20); it is of note that antioxidant supplementation seems to improve the reproductive outcome in PCOS patients (37, 38). Given that CK has been associated with obesity and insulin resistance (19, 39, 40), both features of the metabolic syndrome, then it is not surprising that the association was found in this group of subjects; however, the PCOS subjects here were even more insulin resistant with a higher BMI and waist circumference and it may have been expected that the CK would have been higher than controls, though this was not found.…”

Polikistik over sendromunda Clomiphene sitrat tedavisine eklenen E vitamini takviyelerinin fertilite üzerine etkisi

“…When the literature was reviewed, numerous studies were detected emphasizing that vitamin E can positively affect reproductive physiology by protecting the ovary from reactive oxygen species during luteolysis. Its use with vitamin E and Omega-3 was found to have beneficial effects on total antioxidant capacity, malondialdehyde concentrations, glutathione levels, and catalases activity [18]. In their study conducted by Izadi et al in patients with PCOS, they found that serum total testosterone levels decreased when compared to the placebo group and significantly improved sex hormone binding globulin (SHBG) levels in patients who receive vitamin E and CoQ10 (Coenzyme Q) [19].…”