Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years

Fat intake and asthma in Spanish schoolchildren

“…However, although some authors report an association between the intake of lipids, certain fatty acids and certain foods and asthma (Bolte et al, 2005;Laerum et al, 2007;Olsen et al, 2008), others have found none (Devereux and Seaton, 2005;Almqvist et al, 2007;Kim et al, 2009;de Vries and Howie, 2009). Nevertheless, because of the fact that saturated fatty acids (SFAs) intake among children is very high nowadays, reaching the double of the recommended intake in some cases (Royo-Bordonada et al, 2006;McNeill et al, 2010), SFAs intake could be related to the increase in the prevalence of asthma.…”

Development of the Immune System - Early Nutrition and Consequences for Later Life

“…This shift in the decrease of allergy can be explained since n-3 LCPUFA is incorporated in the membrane of immune cells at the cost of n-6 LCPUFA as arachidonic acid, skewing towards a less inflammatory cytokine surrounding. In contrast, in a clinical study by Almqvist et al, (Almqvist, Garden et al 2007) it is shown that supplementation of n-3 PUFA, starting at a maximum of six months of age, did not prevent children with a family history of asthma from developing atopy, eczema nor asthma at the age of 5 years. Hence discrepancy on effects of n-3 PUFA in prevention of allergic disease exists.…”

Interaction of Asthma and Nutrition: Review

“…38 Almqvist ve ark.nın çalışmasında, diyetle n-3 ve n-6 alımının hırıltılı solunum ile ilişkisinin olmadığı gösterilmiştir. 39 Ço-cuklar üzerinde yapılan bir başka çalışmada, birinci gruptaki çocuklara yüksek n-3 yağ asidi, düşük n-6 yağ asidi içeren diyet verilir iken; ikinci gruba düşük n-3 yağ asidi ve yüksek n-6 yağ asidi içeren diyet verilmiştir. Çalışma sonunda, diyet müdaha-lelerinin astım prevalansı üzerine bir etkisi bulunamamıştır.…”