Olopatadine hydrochloride loaded Kollidon® SR nanoparticles for ocular delivery: Nanosuspension formulation and in vitro–in vivo evaluation

Güven, Umay Merve; Yenilmez, Evrim

doi:10.1016/j.jddst.2019.03.016

Cited by 27 publications

(11 citation statements)

References 56 publications

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“…In comparison with other polymeric nano-formulations with variant polymer ratios such as NP-1, NP-2, NP-3, it was found NP-2 exhibited high drug loading efficiency, along with increasing drug release pattern. Later it was concluded that the formulation could deliver the drug for a longer duration of time, at a sustained rate [ 57 ].…”

Section: Need For Nanomedicine For Ocular Drug Deliverymentioning

confidence: 99%

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

Qamar

Qizilbash

Iqubal

et al. 2020

DDF

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The structure of the eye is very complex in nature which makes it a challenging task for pharmaceutical researchers to deliver the drug at the desired sites via different routes of administration. The development of the nano-based system helped in delivering the drug in the desired concentration. Improvement in penetration property, bioavailability, and residence time has all been achieved by encapsulating drugs into liposomes, dendrimers, solid lipid nanoparticle, nanostructured lipid carrier, nanoemulsion, and nanosuspension. This review puts emphasis on the need for nanomedicine for ocular drug delivery and recent developments in the field of nanomedicine along with recent patents published in the past few years.

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Section: Need For Nanomedicine For Ocular Drug Deliverymentioning

confidence: 99%

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

Qamar

Qizilbash

Iqubal

et al. 2020

DDF

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“…The release profile showed maximum release of 90% in 48 h, while without nanosuspension, time reached 3 h. In addition, the retention study revealed that nanoparticles were washed off the cornea surface within 24 h, but the retention time of drugs has been increased rather than a solution without nanoparticles. Prolonged drug release and retention enhanced patient compliance [ 95 ].…”

Section: Nanoparticles As Biodegradable Nanocarriers For Cornea Drmentioning

confidence: 99%

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

et al. 2020

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During recent decades, researchers all around the world have focused on the characteristic pros and cons of the different drug delivery systems for cornea tissue change for sense organs. The delivery of various drugs for cornea tissue is one of the most attractive and challenging activities for researchers in biomaterials, pharmacology, and ophthalmology. This method is so important for cornea wound healing because of the controllable release rate and enhancement in drug bioavailability. It should be noted that the delivery of various kinds of drugs into the different parts of the eye, especially the cornea, is so difficult because of the unique anatomy and various barriers in the eye. Nanoparticles are investigated to improve drug delivery systems for corneal disease. Biodegradable nanocarriers for repeated corneal drug delivery is one of the most attractive and challenging methods for corneal drug delivery because they have shown acceptable ability for this purpose. On the other hand, by using these kinds of nanoparticles, a drug could reside in various part of the cornea for longer. In this review, we summarized all approaches for corneal drug delivery with emphasis on the biodegradable nanoparticles, such as liposomes, dendrimers, polymeric nanoparticles, niosomes, microemulsions, nanosuspensions, and hydrogels. Moreover, we discuss the anatomy of the cornea at first and gene therapy at the end.

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“…The results showed that the formulation prepared using Eudragit ® RL 100 showed higher EE% than Eudragit ® RS 100 but this difference is not significant (p = 0.22). Several factors can be affect successful entrapment of drug in the NPs; these contain, low drug solubility in the aqueous phase; fast precipitation rate of polymer(s) in the aqueous phase, low viscosity of the internal phase, as well as, drug solubility in the polymer [31][32][33].…”

Section: Measurement Of Ps Pdi Zp and Eementioning

confidence: 99%

“…Complete solution was filtered through 0.22 μm polyamid filter and analyzed using HPLC. Drug content was expressed as EE (%) following Equation 1 [3,32]. EE% = (Actual amount of CVL loaded in NPs / Theoretical amount of CVL loaded in NPs) x 100 Eq.…”

Section: Assessment Of Entrapment Efficiency (Ee)mentioning

confidence: 99%

Evaluation of carvedilol-loaded Eudragit® nanoparticles

Güven¹,

Öztürk²,

Yenilmez³

2020

jrp

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The objective of present study was to prepare positively charged carvedilol-loaded nanoparticles providing a controlled release formulation by spray dryer technique and was to examine the effect of different derivative of Eudragit ® polymers on entrapment efficiency (EE%), dissolution profile and release kinetics. Two nonbiodegradable positively charged polymers, Eudragit ® RS100 and RL100 were used alone or in combination. The prepared formulations were evaluated for their particle size, polydispersity index, zeta potential, in vitro dissolution and in vitro release kinetics study. Particle sizes of placebo nanoparticles and carvedilol loaded nanoparticles were 418.2±18.5/ 402.3±22.0/ 416.3±12.5 and 535.5±13.8/ 529.4±10.2/ 530.4±10.4 nm, respectively with PDI values of approximately 0.4-0.6 for each. Carvedilol loading was resulted in positive electrical charge on nanoparticles. The drug encapsulation efficiency was 68.45±4.67/ 63.58±2.30/ 65.67±4.21. In vitro cumulative release from the nanoparticles was 80-90 % at 48 hour. Morphology and solid state analyzes were performed also in nanoparticles. The results of this research indicate that spray dryer technique is suitable for carvedilol loaded Eudragit ® nanoparticles and no burst effect but a prolonged drug release was observed from formulations.

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Olopatadine hydrochloride loaded Kollidon® SR nanoparticles for ocular delivery: Nanosuspension formulation and in vitro–in vivo evaluation

Cited by 27 publications

References 56 publications

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

Evaluation of carvedilol-loaded Eudragit® nanoparticles

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