Olmesartan ameliorates urinary dysfunction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress

Abstract

Our data suggest that BP, BBF, and oxidative stress may be responsible for the functional changes in HT-related bladder dysfunction. Olmesartan significantly ameliorated this bladder dysfunction.

The angiotensin II receptors type 1 blockage affects the urinary bladder activity in hyperosmolar-induced detrusor overactivity in rats: Preliminary results

“…Cheng et al 16 postulated some pathomechanisms responsible for detrusor motor activity and collagen changes in urinary bladder dysfunctions. An interesting study of Shimizu et al 17 on spontaneously hypertensive rats showed that ACE inhibitors ameliorates urodynamic parameters and urinary bladder oxidative injury as compared to normal rats. Thus, telmisartan also may restore proper urinary bladder blood flow and consequently prevent from oxidative stress induction and bladder damage leading to OAB/DO.…”

Effects of silodosin and tadalafil on bladder dysfunction in spontaneously hypertensive rats: Possible role of bladder blood flow

“…A study showed that reactive oxygen species induce detrusor overactivity through bladder afferent pathway sensitization in rats . Our previous report also showed that bladder tissue MDA levels in SHRs were significantly higher than those in Wistar rats . Strong positive 4‐hydroxy‐2‐nonenal (a marker of oxidative stress), nuclear factor erythroid 2‐related factor 2 (transcription factor) and nerve growth factor (a biomarker of detrusor overactivity) immunoreactivities were observed in the urothelium of the SHRs .…”

“…The data from our previous studies suggested that managing BBF recovery is an important factor in the amelioration of storage symptoms and bladder dysfunction . α 1A ‐Adrenoceptor mRNA is expressed in bladder microvessels in humans and rats .…”

“…They also show decreased BBF and increased micturition frequency compared with the normotensive Wistar rats . Our previous studies have shown that chronic treatment with vasodilators, such as silodosin, nicorandil, olmesartan and hydroxyfasudil, ameliorates urodynamic parameters and increases BBF in SHRs . However, to the best of our knowledge, there are no reports that investigate the effect of tadalafil on bladder overactivity in the SHRs.…”

“…Continuous cystometric studies were carried out to measure the ICI and MVP. In the single cystometry, SVV, post‐residual urine volume and BC were evaluated as described in our previous reports …”