Olive phenolic compounds attenuate deltamethrin-induced liver and kidney toxicity through regulating oxidative stress, inflammation and apoptosis

Maalej, Amina; Mahmoudi, Asma; Bouallagui, Zouhaier; Fki, Ines; Marrekchi, Rim; Sayadi, Sami

doi:10.1016/j.fct.2017.06.010

Cited by 57 publications

(46 citation statements)

References 48 publications

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“…The usage of pesticides is inevitable in contemporary agriculture and increases due to demands of more efficient food production of constantly growing world population (Marín-Benito et al, 2016). However, in spite to beneficial effect on crop yield, significant concern has been raised regarding pesticide adverse effects toward humans and other nontarget organisms (Maalej et al, 2007;Mostafalou and Abdollahi, 2013;De Brito Rodrigues et al, 2017), as well as their retention in soil and water ecosystems (Macneale et al, 2010;Ouyang et al, 2017). To address these issues while simultaneously aiming to provide sustainable food supply, a relatively novel approach to contemporary food production known as "green agriculture" is being increasingly more put in practice (Hjeresen and Gonzales, 2002;EU, 2007).…”

Section: Introductionmentioning

confidence: 99%

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Mužinić

Ramić

Želježić

2018

Environ and Mol Mutagen

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Chlorpyrifos, imidacloprid, and α‐cypermethrin are some of the most widely used insecticides in contemporary agriculture. However, their low‐dose, nontarget genotoxic effects have not been extensively assayed. As one of the most relevant cancer biomarkers, we aimed to assess the aneuploidy due to chromosome missegregation during mitosis. To aim it we treated human lymphocytes in vitro with three concentrations of insecticides equivalents relevant for real scenario exposure assessed by regulatory agencies. We focused on chlorpyrifos as conventional and imidacloprid and α‐cypermethrin as sustainable use insecticides. Cytokinesis‐blocked micronucleus assay was performed coupled with fluorescence in situ hybridization (FISH) with directly labeled pancentromeric probes for chromosomes 9, 18, X and Y. None of the insecticides induced significant secondary DNA damage in terms of micronuclei (MN), nuclear buds (NB), or nucleoplasmic bridges (NPB). However, significant disbalances in chromosomes 9, 18, X and Y, and in insecticide‐treated cells has been observed. According to recent studies, these disbalances in chromosome numbers may be atributted to defect sister chromatid cohesion which contribute to the increase of chromosome missegregation but not to micronuclei incidence. We conclude that tested insecticidal active substances exert chromosome missegregation effects at low concentrations, possibly by mechanism of sister chromatid cohesion. These findings may contribute to future risk assesments and understanding of insecticide mode of action on human genome. Environ. Mol. Mutagen. 60:72–84, 2019. © 2018 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Mužinić

Ramić

Želježić

2018

Environ and Mol Mutagen

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“…Various levels of oxidative stress are attributed to several nutritional, environmental, and/or disease conditions (Bansal & Bilaspuri, 2010;Lanzafame, 2009). Deltamethrin toxicity has been found to increase the lipid peroxidation (Ben Slima et al, 2013;Elsheikh, Galal, & Fadil, 2018), to decrease the activity of antioxidant enzymes (Maalej et al, 2017;Yousef, Awad, & Mohamed, 2006) and to inhibit the antioxidant biomarkers (Abdel-Daim, Abuzead, & Halawa, 2013). Deltamethrin toxicity has been found to increase the lipid peroxidation (Ben Slima et al, 2013;Elsheikh, Galal, & Fadil, 2018), to decrease the activity of antioxidant enzymes (Maalej et al, 2017;Yousef, Awad, & Mohamed, 2006) and to inhibit the antioxidant biomarkers (Abdel-Daim, Abuzead, & Halawa, 2013).…”

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confidence: 99%

“…Experimental toxicity with agriculture insecticide deltamethrin (DM) has been found to induce severe oxidative stress in different organs and tissues. Deltamethrin toxicity has been found to increase the lipid peroxidation (Ben Slima et al, 2013;Elsheikh, Galal, & Fadil, 2018), to decrease the activity of antioxidant enzymes (Maalej et al, 2017;Yousef, Awad, & Mohamed, 2006) and to inhibit the antioxidant biomarkers (Abdel-Daim, Abuzead, & Halawa, 2013). Several antioxidant active substances have been suggested to minimise the adverse effect of oxidative stress (Bansal & Bilaspuri, 2010;Lanzafame, 2009) or to improve the function of the male genital tract in normal animals (Jafaroghli et al, 2014;Lui et al, 2015).…”

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confidence: 99%

Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress

et al. 2018

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This study was carried out to investigate the potential effects of Chlorella vulgaris (CV) on testicular function and oxidant/antioxidant status in normal and deltamethrin‐intoxicated rats. Forty adult male rats were drenched either with normal saline, CV (50 mg/kg), deltamethrin (DM) (3 mg/kg), or CV combined with DM, daily for 8 weeks. At the end of the protocol, the epididymal sperm quality was evaluated and the testicular superoxide dismutase (SOD), catalase enzyme (CAT) and malondialdehyde (MDA), and the serum testosterone levels were estimated. Normal rats treated with CV showed a significant increase in the total sperm number/epididymal tail, testicular SOD, and CAT levels with a significant decrease in the testicular MDA. Deltamethrin intoxication significantly decreased the proportions of motile and live sperm, the testosterone concentration, the testicular SOD and CAT levels, whereas it significantly increased the proportion of abnormal sperm and the testicular MDA. Chlorella vulgaris treatment significantly ameliorated the adverse effects of DM‐intoxication and restored most of the parameters to levels that are comparable to those of the control group. In conclusion, CV administration improved the testicular function of normal rats and ameliorated the effect of severe oxidative stress conditions.

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“…There were no differences found in the expression of p53 mRNA in zebrafish larvae exposed to deltamethrin by Awoyemi et al [17] but Maalej et al [48] observed a significant increase, showing that deltamethrin treatment-induced oxidative damage and inflammation through increasing cox-2 expression and initiates a series of cell death signaling events, including p53 activation, leading to DNA fragmentation and apoptosis.…”

Section: Discussionmentioning

confidence: 88%

Toxicity of Deltamethrin to Zebrafish Gonads Revealed by Cellular Biomarkers

Petrovici

Strungaru

Nicoară

et al. 2020

JMSE

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Deltamethrin is responsible for health and reproduction problems both in mammals and aquatic organisms. In this study, zebrafish adults were exposed for 15 days to 0.25, 0.5, 1, and 2 μg L−1 non-lethal concentrations of deltamethrin, knowing that is used worldwide on agricultural crops. We investigated the chronic effects of deltamethrin on gonads by histopathological examination, immunohistochemistry, and immunofluorescence using biomarkers for apoptosis (anti-p53, anti-H2A.XS139ph antibodies, and TUNEL assay), oxidative stress (anti-Cox4i1 antibody) and proliferation (anti-PCNA antibody). Among the histopathological changes, the apoptotic response was elevated in ovary and testis of deltamethrin exposed groups as it was seen in the IHC and IF for p53, H2A.XS139ph, and confirmed by TUNEL assay. These were observed in the case of all studied concentrations compared with the control group. Thereby, the gonadal tissue exhibited an up-regulated activity of this cell-death signaling markers, while the proliferation marker (PCNA) increased in the ovary due to its presence not only in primary growth and cortical-alveolar stage follicles but also in atretic follicles, meanwhile decreased notably in the testis. Cox4i1, a mitochondrial marker, decreased both in ovary and testis during deltamethrin treatment, probably inhibited by the overproduction of the free radicals after pesticide exposure.

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Olive phenolic compounds attenuate deltamethrin-induced liver and kidney toxicity through regulating oxidative stress, inflammation and apoptosis

Cited by 57 publications

References 48 publications

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α‐Cypermethrin

Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress

Toxicity of Deltamethrin to Zebrafish Gonads Revealed by Cellular Biomarkers

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