Olive oil promotes wound healing of mice pressure injuries through NOS-2 and Nrf2

Abstract

The pressure injury environment is characterized by overproduction of reactive oxygen species and exacerbated inflammation, which impair the healing of these lesions. Mediterranean-like diet may be a good intervention to improve the healing of pressure injury owing to its anti-inflammatory and antioxidant components. Thus, this study evaluated the hypothesis that olive oil, as a main source of lipid in Mediterranean diet, could improve cutaneous wound healing of pressure injury in mice. Male Swiss mice were randomly divided into standard, olive oil, or soybean oil plus olive oil groups and fat represented 10% of total calories in all groups. Four weeks after the beginning of diet administration, 2 cycles of ischemia–reperfusion (IR) by external application of 2 magnets disks were performed in the dorsal skin to induce pressure injury formation. Fourteen days after the end of the second IR cycle, olive oil-based diet reduced neutrophils cells and cyclooxygenase-2 protein expression and increased nitric oxide synthase-2 and protein and lipid oxidation. Olive oil based-diet also increased nuclear factor erythroid 2-related factor 2 protein expression and collagen type I precursor protein expression. In addition, administration of olive oil-based diet promoted wound closure at 7, 10, and 14 days after the end of the second IR cycle. These findings support the hypothesis that olive oil-based diet improves cutaneous wound healing of pressure injury in mice through the reduction of inflammation and stimulation of redox equilibrium.

Olive‐Oil‐Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF‐κB Pathway

“…By demonstrating that EVOO phenols exert anti‐inflammatory effects on human keratinocytes, our study not only extends these previous findings to also encompass HTy‐Ac, but it shows that human keratinocytes are direct targets of EVOO phenols, which appears translationally interesting in the context of inflammatory skin disorders, as also encouraged by the mentioned studies investigating the potential use of olive oil‐derived compounds in the field of dermatology …”

“…In this regard, a polyphenol‐based cosmeceutical containing olive polyphenol extract, exhibited positive skin effects . Along the same lines, an olive oil‐based diet (10% of total calories) improved cutaneous wound healing of pressure injury in mice . Besides, ex vivo topical administration of olive oil (0.01 mg mL –1 ) was capable of attenuating the reduction in epidermis and dermis thickness and collagen fiber content induced by chronic stress in human skin .…”

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

“…The production of NOS2/NO contributes to chronic inflammation of ulcers through stimulating the synthesis of prostaglandin E2 and cyclooxygenase-2 [36]. Except for the inflammatory factors, the expression of oxygen-free radicals such as SOD was another important factor for the occurrence of injury and ulcer [37]. Furthermore, EGF is the ligand of EGFR, which is secreted in the gastrointestinal tract and could facilitate epithelial cell repair, reduce gastric acid secretion and promote the healing of ulcers [38].…”

Study on the Protective Effect and the Metabolomics Features of Rutaecarpine on Ethanol-induced Acute Gastric Ulcer

“…In addition, this study used kits to detect the expression of cytokines related to gastritis. The expression of antioxidases, such as SOD and CAT, play an advantageous role in protecting the stomach from ethanol damage [18] . In addition, EGF is secreted in the gastrointestinal tract and could reduce gastric acid secretion, maintain structural integrity and promote the healing of ulcers [19] .…”