Olive Oil Polyphenols Decrease LDL Concentrations and LDL Atherogenicity in Men in a Randomized Controlled Trial

Hernáez, Álvaro; Remaley, Alan T.; Farràs, Marta; Fernández‐Castillejo, Sara; Subirana, Isaac; Schröder, Helmut; Fernández-Mampel, Mireia; Muñoz-Aguayo, Daniel; Sampson, Maureen; Solà, Rosa; Farré, Magı́; Torre, Rafael de la; López-Sabater, María-Carmen; Nyyssönen, Kristiina; Zunft, Hans-Joachim F.; Covas, Marı́a-Isabel; Fitó, Montserrat

doi:10.3945/jn.115.211557

Cited by 80 publications

(72 citation statements)

References 31 publications

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“…This health claim established literally that “olive oil polyphenols contribute to the protection of blood lipids from oxidative stress and also stated that the claim may be used only for olive oil containing at least 5 mg of HTyr and its derivatives (e.g., oleuropein complex and Tyr) per 20 g of olive oil; in order to bear the claim information shall be given to the consumer that the beneficial effect is obtained with a daily intake of 20 g of olive oil”. Olive oil PC have also positive effects on other physiological parameters such as inflammatory markers, platelet and cellular function and cardiovascular health [8,25,26,27,28,29,30]. …”

Section: Market Needs For Functional Oilsmentioning

confidence: 99%

State of the Art on Functional Virgin Olive Oils Enriched with Bioactive Compounds and Their Properties

Reboredo‐Rodríguez

Figueiredo-González

González-Barreiro

et al. 2017

IJMS

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Virgin olive oil, the main fat of the Mediterranean diet, is per se considered as a functional food—as stated by the European Food Safety Authority (EFSA)—due to its content in healthy compounds. The daily intake of endogenous bioactive phenolics from virgin olive oil is variable due to the influence of multiple agronomic and technological factors. Thus, a good strategy to ensure an optimal intake of polyphenols through habitual diet would be to produce enriched virgin olive oil with well-known bioactive polyphenols. Different sources of natural biological active substances can be potentially used to enrich virgin olive oil (e.g., raw materials derived from the same olive tree, mainly olive leaves and pomaces, and/or other compounds from plants and vegetables, mainly herbs and spices). The development of these functional olive oils may help in prevention of chronic diseases (such as cardiovascular diseases, immune frailty, ageing disorders and degenerative diseases) and improving the quality of life for many consumers reducing health care costs. In the present review, the most relevant scientific information related to the development of enriched virgin olive oil and their positive human health effects has been collected and discussed.

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Section: Market Needs For Functional Oilsmentioning

confidence: 99%

State of the Art on Functional Virgin Olive Oils Enriched with Bioactive Compounds and Their Properties

Reboredo‐Rodríguez

Figueiredo-González

González-Barreiro

et al. 2017

IJMS

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“…4 Hypomethylation of GABRR1 is associated with lower HII levels (more antiinflammatory HDLs), although the variability explained is small. To the best of our knowledge, there is no relation between GABRR1 and lipid metabolism or functionality.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidized LDLs were prepared from a pool of LDLs, isolated from plasma of 20 healthy participants by density gradient ultracentrifugation. 4 LDLs were oxidized as previously described, 3 diluted to 100 mg/L LDL protein and stored at -80ºC upon use. Finally, 5 µL of ABDP from the volunteers was incubated with H2DCF (final concentration: 3 µg/mL) and oxidized LDLs (final concentration: 1.5 µg/mL) in 96-well, black polystyrene plates, at 37ºC.…”

Section: Hdl Antioxidant Capacitymentioning

confidence: 99%

DNA Methylation and High-Density Lipoprotein Functionality—Brief Report

Sayols-Baixeras

Hernáez

Subirana

et al. 2017

ATVB

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Objective— The function of high-density lipoproteins (HDLs) may better reflect their atheroprotective role, compared with HDL-cholesterol levels. The association between DNA methylation and HDL function has not yet been established. Approach and Results— We designed an epigenome-wide association study including 645 individuals from the REGICOR study (Registre Gironi del Cor). We determined DNA methylation from peripheral blood cells using the HumanMethylation450 array. We analyzed HDL functionality by determining HDL cholesterol efflux capacity and HDL inflammatory index. We discovered 3 methylation sites located in HOXA3 , PEX5 , and PER3 related to cholesterol efflux capacity and 1 located in GABRR1 related to HDL inflammatory index. Using a candidate gene approach, we also found 2 methylation sites located in CMIP related to cholesterol efflux capacity. Conclusions— We identified 6 potential loci associated with HDL functionality in HOXA3 , PEX5 , PER3, CMIP , and GABRR1 . Additional studies are warranted to validate these findings in other populations.

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“…Efectivamente, el consumo específico de aceite de oliva extra virgen con alto contenido de polifenoles incrementa los niveles de colesterol HDL y modifica la composición lipídica y proteica así como las actividades funcionales de las partículas de HDL, en comparación con aceite de oliva bajo en polifenoles [35][36][37][38] . Adicionalmente, la manipulación selectiva del nivel de compuestos fenólicos presentes en aceite de oliva ha demostrado su acumulación en las HDL circulantes, aumentado el tamaño, reduciendo el contenido de triglicéridos y mejorando el daño oxidativo de estas partículas de HDL 39,40 .…”

Section: Figura 2 Transición Entre Funcionalidad Normal Y Alterada Dunclassified

Impacto de la dieta mediterránea sobre las lipoproteínas de alta densidad

Echeverría

Rigotti

2017

Rev Chil Cardiol

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Olive Oil Polyphenols Decrease LDL Concentrations and LDL Atherogenicity in Men in a Randomized Controlled Trial

Abstract: The consumption of olive oil polyphenols decreased plasma LDL concentrations and LDL atherogenicity in healthy young men. This trial was registered at www.controlled-trials.com as ISRCTN09220811.

Cited by 80 publications

References 31 publications

State of the Art on Functional Virgin Olive Oils Enriched with Bioactive Compounds and Their Properties

State of the Art on Functional Virgin Olive Oils Enriched with Bioactive Compounds and Their Properties

DNA Methylation and High-Density Lipoprotein Functionality—Brief Report

Impacto de la dieta mediterránea sobre las lipoproteínas de alta densidad

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