Olive oil in parenteral nutrition

Sala‐Vila, Aleix; Barbosa, Vera M; Calder, Philip C.

doi:10.1097/mco.0b013e32802bf787

Cited by 103 publications

(85 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently developed lipid emulsions have substituted soybean oil with oils rich in medium chain triacylglycerols (MCT), n-9 MFA (ref. 244 ) and n-3 PUFA (ref. 245,246 ).…”

Section: Critically Ill Patients Cancer and Other Chronic Diseasesmentioning

confidence: 99%

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Kremmyda¹,

Tvrzická²,

Staňková³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

152

134

View full text Add to dashboard Cite

Background. This is the second of two review parts aiming at describing the major physiological roles of fatty acids, as well as their applications in specific conditions related to human health.Results. The review included the current literature published in Pubmed up to March 2011. In humans, fatty acids are a principle energy substrate and structural components of cell membranes (phospholipids) and second messengers. Fatty acids are also ligands of nuclear receptors affecting gene expression. Longer-chain (LC) polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid are precursors of lipid mediators such as eicosanoids (prostaglandins, leukotrienes, thromboxanes), resolvins and neuroprotectins. Lipid mediators produced by EPA and DHA (LC n-3 PUFA; mainly found in oily fish) are considered as inflammation-resolving, and thus, fish oil has been characterised as antiinflammatory. Recommendations for EPA plus DHA intake from oily fish vary between 250-450 mg/day. Dietary reference values for fat vary between nutrition bodies, but mainly agree on a low total and saturated fat intake. The existing literature supports the protective effects of LC n-3 PUFA (as opposed to n-6 PUFA and saturated fat) in maternal and offspring health, cardiovascular health, insulin sensitivity, the metabolic syndrome, cancer, critically ill patients, and immune system disorders.Conclusion. Fatty acids are involved in multiple pathways and play a major role in health. Further investigation and a nutrigenomics approach to the effects of these biocompounds on health and disease development are imperative and highlight the importance of environmental modifications on disease outcome.humans. Thus, these FA may be characterised as conditionally essential depending on EFA availability. Genetic variation in human desaturase genes affects FA metabolism, plasma lipid profiles, and risk of disease development [5][6][7] . Recommendations for minimum dietary intake of EPA plus DHA vary between 250-450 mg/day 8 , especially for pregnant women and those of reproductive age. Rich sources of LC n-3 PUFA are fish oils and the flesh of oily fish, whereas non-oily (white) fish contain them but in lower amounts.Long-chain PUFA with 18-20 carbon atoms, including EPA and AA, are precursors of eicosanoids (prostaglandins, leucotrienes and thromboxanes), which have a broad scale of regulatory, autocrine and paracrine effects. Long-chain PUFA with 20 and 22 carbon atoms are precursors of autacoids -resolvins (resolution phase interaction products), lipoxins and neuroprotectins 9 . FA are also ligands of nuclear receptors which take part in the subcellular control of metabolic pathways. Covalent modification of proteins by FA acylation enables their incorporation into membranes. Hydroxy FA are activators of some nuclear factors and are responsible for the expression of proinflammatory cytokines (interleukin (IL)-1,

show abstract

“…Recently developed lipid emulsions have substituted soybean oil with oils rich in medium chain triacylglycerols (MCT), n-9 MFA (ref. 244 ) and n-3 PUFA (ref. 245,246 ).…”

Section: Critically Ill Patients Cancer and Other Chronic Diseasesmentioning

confidence: 99%

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Kremmyda¹,

Tvrzická²,

Staňková³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

152

134

View full text Add to dashboard Cite

show abstract

“…Existen por tanto múltiples estudios que comparan SMOFlipid ® frente a otros lípidos (no con oleico) (23-25) y de Clinoleic ® frente a otros lípidos no enriquecidos en omega 3 (26)(27)(28)(29), pero muy pocos comparativos entre el oleico y SMOFlipid ® en adultos. En las Guías de Nutrición Parenteral para el paciente crítico realizadas por la ESPEN se reconoce que el lípido basado en omega 9 (Clinoleic ® ) es bien tolerado en pacientes críticos, y que la adición de ácido eicosapentaenoico (EPA) y ácido docosahexaenoico (DHA) a las emulsiones lipídicas ha demostrado un efecto beneficioso sobre los procesos inflamatorios (30).…”

Section: Discussionunclassified

Estudio comparativo de la efi cacia y seguridad de una nutrición parenteral formulada con dos lípidos distintos: SMOFlipid® frente a Clinoleic®. Estudio preliminar

Aranaga

Vales²,

Navarro

et al. 2016

Nutr Hosp

View full text Add to dashboard Cite

Introducción: la composición lipídica de las fórmulas de nutrición parenteral (NP) se postula como posible factor de evolución clínica.Objetivo: evaluar las diferencias en efi cacia y seguridad de dos emulsiones lipídicas en NP.Material y métodos: estudio clínico prospectivo de pacientes posquirúrgicos sometidos a NP durante más de 7 días en un periodo de 2 años.Se administraron de forma indistinta 2 tipos de emulsiones lipídicas: enriquecida con ácidos grasos omega 3 (SMOFlipid Fresenius Kabi®) o conácido oleico omega 9 (Clinoleic Baxter®). Se analizaron variables epidemiológicas, analíticas, complicaciones infecciosas y mortalidad.Resultados: se estudió un total de 154 pacientes con edad media de 64,36 ± 13,73 años, de los que 95 eran hombres (61%), 78 (51%)recibieron SMOFlipid® y 76 (49%) Clinoleic®. La estancia media fue de 16,91 ± 4,23 días, la duración de la NP 9,68 ± 3,25 días y la mortalidaddel 11%. Se diagnosticaron 58 (37%) infecciones. No existieron diferencias signifi cativas en cuanto a los parámetros analíticos lipídicos,hepáticos o nutricionales (medidos al inicio y al 7.º día) ni en su evolución (estancia media, complicaciones infecciosas ni mortalidad) entre losdos grupos de pacientes.Conclusión: los pacientes sometidos a NP presentan similares características evolutivas con independencia de la emulsión lipídica utilizada.La bibliografía actual apunta a un benefi cio de la disminución del aporte de ácidos grasos omega 9, pero no se han encontrado diferenciassignifi cativas entre las fórmulas comparadas.

show abstract

“…As alterações descritas parecem não prejudicar a evolução de pacientes estáveis recebendo EL parenterais ricas em TCL ω-6, entretanto, podem vir a agravar a condição clínica de pacientes com risco de infecção ou sepse (Sala-Vila et al, 2007). Dessa maneira, apesar de alguns estudos não demonstrarem efeitos prejudiciais do uso de TCL ω-6 no sistema imune (Lenssen et al, 1998;Sedman et al, 1991;Gogos et al, 1990;Dionigi et al, 1985), atualmente busca-se evitar o uso de EL rica em TCL ω-6 em pacientes imuno-comprometidos ou em risco de imunossupressão (Campos et al, 2002).…”

Section: Impacto Das Emulsões Lipídicas Sobre O Sistema Imuneunclassified

“…1) EL ricas em TCL estão associadas à redução de algumas funções do sistema imune e, atualmente, preconiza-se evitar seu uso em pacientes críticos não estáveis (Sala-Vila et al, 2007;Campos et al, 2002;Jensen et al, 1990;Sedman et al, 1990;Hamawy et al, 1985;Sobrado et al, 1985;Nordenstrom et al, 1979);…”

Section: Dos Grupos Experimentaisunclassified

“…Considerando-se que AG ω-9 são associados com efeito neutro sobre funções imunes (Sala-Vila et al, 2007;El Seweidy et al, 2005;GarnachoMontero et al, 2002;Moussa et al, 2000;Baumann et al, 1999), pode-se sugerir que o efeito neutro observado por SMOF esteja relacionado com seu conteúdo deste AG. 2) A fim de compreender porque óleo de peixe associado a TCM/TCL alterou número de macrófagos fagocitantes e sua presença na EL SMOF não teve o mesmo efeito, dentro das condições do presente estudo pretende-se em breve:…”

Section: Variáveis Imunológicasunclassified

See 1 more Smart Citation

Efeito de emulsão lipídica parenteral composta por mistura de triglicérides de cadeia média e óleos de soja, oliva e peixe sobre a migração e fagocitose de leucócitos de ratos

Campos¹

View full text Add to dashboard Cite

Olive oil in parenteral nutrition

Cited by 103 publications

References 60 publications

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Estudio comparativo de la efi cacia y seguridad de una nutrición parenteral formulada con dos lípidos distintos: SMOFlipid® frente a Clinoleic®. Estudio preliminar

Efeito de emulsão lipídica parenteral composta por mistura de triglicérides de cadeia média e óleos de soja, oliva e peixe sobre a migração e fagocitose de leucócitos de ratos

Contact Info

Product

Resources

About