Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model

Szabó, László; Molnar, Richard; Tomesz, Andras; Deutsch, Arpad; Darago, Richard; Varjas, Tímea; Ritter, Zsombor; Szentpéteri, József; Andreidesz, Kitti; Máthé, Domokos; Hegedüs, Imre; SIK, Attila Gabor; Budán, Ferenc; Kiss, István

doi:10.3390/nu14040908

Cited by 7 publications

(3 citation statements)

References 150 publications

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“…Szabo et al. also found that olive oil (EVOO) improved the hypomethylation of LINE-1 reverse transcription transposon DNA in an environmental carcinogen model compared to controls, resulting in reduced tumor incidence ( 82 ). Therefore, it can be considered that the treatment of gynecological tumors by targeting and regulating LINE-1 hypomethylation.…”

Section: Line-1 As a Therapeutic Target For Gynecologic Tumorsmentioning

confidence: 99%

Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors

Qin

Li³

et al. 2023

Front. Oncol.

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The retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-1 is involved in the development of various diseases and also plays an important role in the immune regulation of the organism. The expression of LINE-1 in gynecologic tumors suggests that it is expected to be an independent indicator for early diagnosis and prognosis, and also, as a therapeutic target, LINE-1 is closely associated with gynecologic tumor prognosis. This article discusses the function of LINE-1 in the diagnosis, treatment, and prognosis of ovarian, cervical, and endometrial malignancies, as well as other gynecologic malignancies. It offers fresh perspectives on the early detection of tumors and the creation of novel anti-tumor medications.

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Section: Line-1 As a Therapeutic Target For Gynecologic Tumorsmentioning

confidence: 99%

Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors

Qin

Li³

et al. 2023

Front. Oncol.

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“…Polyphenols possess multifarious beneficial in vivo and clinical health effects, and their details are out of the scope of this review article. In summary, the evident antioxidant and reactive oxygen species inhibitory effects of polyphenols promote the following intracellular signal transduction and regulation process: they downregulate inflammatory proteins (for example IL-1, IL-6, TNFα, mTOR, Nuclear Factor-κB) and also oncogenes (for example C-MYC, RAS, NOTCH) and by the time upregulate tumor suppressor genes (for example SIRT, PTEN, P53) expression through epigenetic factors, such as histone acetylation, DNA methylation, and microRNA expression) [ 29 , 30 , 31 , 32 ]. These molecular effects and intracellular signals lead ultimately to the well-known clinically proven cardiovascular protective, anticarcinogen, antidiabetic, antimicrobial, etc.…”

Section: The Beneficial Effects Of Polyphenols On Health and Its Mole...mentioning

confidence: 99%

The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc

Hegedüs

Andreidesz

Szentpéteri

et al. 2022

IJMS

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Nutritional interventions may highly contribute to the maintenance or restoration of human health. Grapes (Vitis vinifera) are one of the oldest known beneficial nutritional components of the human diet. Their high polyphenol content has been proven to enhance human health beyond doubt in statistics-based public health studies, especially in the prevention of cardiovascular disease and cancer. The current review concentrates on presenting and classifying polyphenol bioactive molecules (resveratrol, quercetin, catechin/epicatechin, etc.) available in high quantities in Vitis vinifera grapes or their byproducts. The molecular pathways and cellular signaling cascades involved in the effects of these polyphenol molecules are also presented in this review, which summarizes currently available in vitro and in vivo experimental literature data on their biological activities mostly in easily accessible tabular form. New molecules for different therapeutic purposes can also be synthesized based on existing polyphenol compound classes available in high quantities in grape, wine, and grape marc. Therefore an overview of these molecular structures is provided. Novel possibilities as dendrimer nanobioconjugates are reviewed, too. Currently available in vitro and in vivo experimental literature data on polyphenol biological activities are presented in easily accessible tabular form. The scope of the review details the antidiabetic, anticarcinogenic, antiviral, vasoprotective, and neuroprotective roles of grape-origin flavonoids. The novelty of the study lies in the description of the processing of agricultural by-products (grape seeds and skins) of industrial relevance, and the detailed description of the molecular mechanisms of action. In addition, the review of the clinical therapeutic applications of polyphenols is unique as no summary study has yet been done.

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“…However, cancer is still, globally, the second leading cause of death (with approximately 9.6 million deaths in 2018) [4] and is also the greatest disease burden. Therefore, novel chemopreventive strategies are warranted to enhance anticarcinogen mechanisms [5][6][7][8][9][10]. In vitro studies and in vivo animal experiments suggest antimutagenic and anticarcinogenic effects of flavonoids [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

Molnar

Szabó

Tomesz

et al. 2022

Cells

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Polyphenols are capable of decreasing cancer risk. We examined the chemopreventive effects of a green tea (Camellia sinensis) extract, polyphenol extract (a mixture of blackberry (Rubus fruticosus), blackcurrants (Ribes nigrum), and added resveratrol phytoalexin), Chinese bayberry (Myrica rubra) extract, and a coffee (Coffea arabica) extract on 7,12-dimethylbenz[a]anthracene (DMBA) carcinogen-increased miR-134, miR-132, miR-124-1, miR-9-3, and mTOR gene expressions in the liver, spleen, and kidneys of CBA/Ca mice. The elevation was quenched significantly in the organs, except for miR-132 in the liver of the Chinese bayberry extract-consuming group, and miR-132 in the kidneys of the polyphenol-fed group. In the coffee extract-consuming group, only miR-9-3 and mTOR decreased significantly in the liver; also, miR-134 decreased significantly in the spleen, and, additionally, miR-124-1 decreased significantly in the kidney. Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-κB; as well as oncogenes, namely RAS and MYC. The examined chemopreventive agents, besides the obvious antioxidant and anti-inflammatory effects, mainly blocked the mentioned DMBA-activated factors and the mitogen-activated protein kinase (MAPK) as well, and, at the same time, induced PTEN as well as SIRT tumor suppressor genes.

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Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model

Cited by 7 publications

References 150 publications

Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors

Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors

The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

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