Olive oil based nutrition in multiple trauma patients: a pilot study

Abstract

Our findings suggest a good tolerance, a decrease in blood glucose, clinically relevant shortening of ICU stay, and shorter time on mechanical ventilation for patients treated with olive oil based than with conventional glucose-heavy nutrition.

Olive oil in parenteral nutrition

“…In burn patients, ClinOleic administration was associated with better liver function, although there was no impact on clinical outcomes [54 ]. The study design used by Huschack et al [53 ] does not permit the many advantages observed in the group receiving ClinOleic to be ascribed to the emulsion because this group also received a different pattern of energy supply compared with the Lipofundin group. Clearly more studies of ClinOleic in these patient groups are required, and future clinical studies of ClinOleic should include evaluation of oxidative stress markers and immune function as well as of clinical outcomes [62].…”

“…This study indicates that ClinOleic is safe to use in burns patients and that it may offer advantages over some other lipid emulsions in terms of preventing liver dysfunction. Huschak et al[53 ] also compared ClinOleic with Lipofundin in trauma patients in an open pilot study.…”

Fish oil in critical illness

“…Soybean oil (SBO)-based lipid emulsions, which are rich in n-6 polyunsaturated longchain triglycerides, have been the standard for lipidbased parenteral nutrition for a long time. In spite of long-term experience using these lipids, which have a good safety profile, experimental and clinical investigations have reported less desirable results (compared with newer emulsions) in terms of pathophysiologic and immunologic profiles [3][4][5][6]. Fish oil-based lipid emulsions, which are rich in n-3 lipids, are now available for parenteral nutrition.…”

Maximizing efficacy from parenteral nutrition in critical care: Appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sources

“…Although they observed no differences in outcome, a statistically higher number of patients experienced liver function abnormalities with the MCT/LCT emulsion. Huschak et al [71] randomized multiple trauma patients to PN that was olive oil based or to standard glucosebased PN. These authors hypothesized that an olive oil-based PN formulation would reduce the hyperglycemic complications associated with glucose-based PN.…”