Olive oil based novel thermo-reversible emulsion hydrogels for controlled delivery applications

Abstract

Gels have been considered as a popular mode of delivering medicament for the treatment of sexually transmitted diseases (STDs) (e.g. human immunodeficiency virus, bacterial vaginosis, epididymitis, human papillomavirus infection and condylomata acuminata etc.). The present study discusses the development of novel olive oil based emulsion hydrogels (EHs) using sorbitan monopalmitate as the structuring agent. The developed EHs may be tried as drug delivery vehicle for the treatment of STDs. The formation of EHs was confirmed by fluorescence and confocal microscopy. FTIR studies suggested intermolecular hydrogen bonding amongst the components of the EHs. X-ray diffraction study suggested the amorphous nature of the EHs. The developed EHs have shown non-Newtonian flow behavior. The EHs were found to be biocompatible. The formulations were able to effectively deliver two model antimicrobial drugs (e.g. ciprofloxacin and metronidazole), commonly used in the treatment of the STDs.

Physical and mechanical properties of sunflower oil and synthetic polymers based bigels for the delivery of nitroimidazole antibiotic – A therapeutic approach for controlled drug delivery

“…AlphaE ATR-FTIR, Bruker, USA was used for the FTIR analysis of the bigels in the wavenumber range of 450-4000 cm À1 [29].…”

Genipin-Crosslinked Gelatin-Based Emulgels: an Insight into the Thermal, Mechanical, and Electrical Studies

“…The xerogels were with platinum prior to visualization under the SEM (25). The infrared spectroscopy of the emulgels and drugloaded emulgels were recorded in the range of 400-4000 cm using Bruker ALPHA-E FTIR spectrophotometer (USA) (26).…”

Olive oil and hyperthermal water bigels for cosmetic uses

“…When only the internal phase is gelled they behave mainly like suspensions made of soft (and deformable) particles with a maximum packing fraction according to the particle rheological properties [6]. When both phases are structured a more complex behaviour, according to the properties of both phases, is observed and the systems can be classified as ''bigels" or ''biphasic gels" [5,7,8]. Emulgels and bigels are particularly interesting owing to their potential use in the cosmetic and pharmaceutical area because they can merge the advantages of emulsions and gels (both hydrogels and organogels) to control drug delivery for topical and transdermal use [5].…”

“…Singh et al [8] studied the microscopic morphology of samples and the rheological properties in terms of viscosities and 'creep and recovery' tests; the same group carried out also small amplitude oscillation tests for similar systems [7] and fluorescent microphotographs were moreover taken in their work based on carbopol-based bigels [15]. Texture analysis (creep recovery tests) were also taken by Satapathy et al [4] in their study comparing gelatin-based hydrogels, emulsion hydrogels, and bigels, while Rehman et al [16] characterised the polarized optical microscopy, viscosity and texture properties of polymer-fish oil bigels.…”