Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis

Consumption of Terpenoids-Rich Padina pavonia Extract Attenuates Hyperglycemia, Insulin Resistance and Oxidative Stress, and Upregulates PPARγ in a Rat Model of Type 2 Diabetes

“…Hyperglycemia and hyperlipidemia were associated with increased generation of ROS, oxidative stress, and inflammation [15,86]. The role of ROS in liver injury has been established by studies showing that reduction of ROS can protect against hepatocyte damage induced by several insults [87][88][89]. HFD/STZ diabetic rats in this study showed excessive production of ROS associated with increased MDA and NO.…”

Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressingIL-1βgene expression in male rats

“…The metabolites of DIC can elevate the production of ROS via the induction of redox imbalance and mitochondrial dysfunction (Moreno-S anchez et al 1999). Hepatocyte damage by DIC's generation of extra ROS has been well documented (Elgebaly et al 2018;Mahmoud et al 2017). Thus, it is reasonable to assume that high levels of antioxidants would be required to ameliorate DIC-induced toxicity.…”

Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage

“…Oleuropein and hydroxytyrosol, as major compounds of olive leaves, have been reported to exert numerous pharmacological properties, including anticancer, antidiabetic, and anti-inflammatory activities [ 14 ]. Recently, the hepatoprotective activity of olive leaves against damage induced by CCl 4 [ 24 , 25 ], cadmium [ 26 , 27 ], paracetamol [ 28 ], thioacetamide [ 29 ], ethanol [ 5 ], fluoxetine [ 30 ] and deltamethrin [ 31 ] has receieved increasing interest in animal experiemts. However, available data about the hepatoprotective effect of olive leaf extracts or their major constituents are still scarce.…”