Olive Leaf Polyphenols Loaded Mucoadhesive Oral Films

Abstract

Among drug delivery systems, mouth dissolving films (MDFs) are a form of drug administration with many advantages. Some problems could be experienced, primarily in pediatric and geriatric patients with conventional drug delivery methods as swallowing. It is of great convenience to dispensing the drug with a film dispersed in the mouth in such cases. In this study, for the preparation of films, the solvent casting method was preferred. The effect of biopolymer ratio and loaded olive leaf extract on the film properties were investigated with the central composite experimental design. Characterization studies of the prepared films were done with AFM, SEM, and FTIR analysis. Based on the characterization studies, the four best formulations were chosen, and further investigations were focused on these formulations. Formulation 8 was chosen as the optimum formulation among 17 formulations due to its better film properties as flexibility and homogeneity, lower disintegration time 200s, and a higher antioxidant capacity 3.21 mM TEAC/g MDF. The obtained data revealed that it is possible to deliver olive leaf polyphenols with the prepared mouth dissolving films.

The effects of olive leaf addition and storage conditions on the bioactive components and some quality parameters of “Patos” olive oils

“…In a previous study, Köse et al (2021) examined the total phenolic contents and antioxidant capacities of Gemlik‐cultivar olives harvested from Fethiye district of Muğla province. The authors concluded that the ABTS value of green olives was found to range between 403.10 and 502.77 μmol Trolox/100 g.…”

Recent advances in functionally modified polymers for mucoadhesive drug delivery

“…The bypass of first-pass metabolism along with direct systemic delivery via transepithelial transport increases therapeutic effectiveness and decreases dosage frequency which is of great interest for patients. This advantage would be a boon to geriatric patients 4 suffering from Parkinson's disease related dysphagia, coma and other age related discomforts.…”