Olive, grass or both? Molecular diagnosis for the allergen immunotherapy selection in polysensitized pollinic patients

Moreno, C; Justicia, José L; Quiralte, Joaquín; Moreno-Ancillo, A; Iglesias-Cadarso, Alfredo; Torrecillas, M.; Labarta, N.; Garcia, Mario; Dávila, Ignacio

doi:10.1111/all.12474

Cited by 53 publications

(40 citation statements)

References 24 publications

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“…At Case series or poor-quality cohort studies that fail to clearly define comparison C Favorable but no groups and/or fail to objectively measure exposures and outcomes (preferably conclusive blinded) and/or fail to identify or appropriately control known confounders and/or fail to ensure complete and sufficiently prolonged follow-up immune response to and clinical benefit from AIT [25]. The molecular-based allergy (MA) diagnosis is an approach to define the allergen sensitization profile of a patient using purified natural or recombinant allergen on singleplex or multiplex measurement platforms [26], and may improve the selection of specific AIT for pollen [24,[27][28][29] and other allergens [30,31]. Thus, the recognition of the sensitization profile (identification of primary sensitization markers with respect to detection of specific IgE against cross-reactive allergen molecules) could better define the relevant allergens in each patient [32][33][34].…”

Section: Main Immunological Changes Induced By Aitmentioning

confidence: 99%

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

Domínguez‐Ortega

Delgado

Blanco

et al. 2017

J Investig Allergol Clin Immunol

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Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations. A systematic search of MEDLINE, Cochrane, and Clinical Trials databases from 2000 to April of 2016 was carried out by a panel of experts from the Spanish Allergy and Clinical Immunology Scientific Society. Relevant studies prior to the year 2000 included in ulterior systematic reviews were also considered. More than 4000 articles were identified during the search and 241 were selected to retrieve available evidence on AIT, which was graded according to the Oxford classification. All the group members reviewed the resulting text until the final version reached the consensual agreement. A summary of recommendations on the more relevant topics are proposed. The role of AIT as a valuable therapeutic strategy for prevention of exacerbation and progressive decline in lung function is highlighted. Future research should include specific tools for asthma evaluation when assessing AIT effectiveness in asthmatic patients. ResumenEl asma se asocia frecuentemente con alergia, entendida ésta como la producción de IgE específica frente a alérgenos ambientales. Actualmente, existen dos tipos de inmunoterapia específica con alérgenos (ITE) para la práctica clínica habitual: subcutánea y sublingual, ambas indicadas en el tratamiento de la rinitis y la conjuntivitis alérgicas. Sin embargo, su papel en el asma resulta todavía controvertido. Dominguez-Ortega J, et al.

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Section: Main Immunological Changes Induced By Aitmentioning

confidence: 99%

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

Domínguez‐Ortega

Delgado

Blanco

et al. 2017

J Investig Allergol Clin Immunol

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“…In the last decade, the gradual development of specific immunological and molecular biology techniques has allowed us to reach a more accurate diagnosis through the identification of allergenic components (molecular diagnosis) 1, 2, 3, 4 and it has also helped to develop AIT treatments with a precise allergen content and, therefore, more effective and safer. Beyond the progress in diagnosis, the publication of European guidelines 5 defining the methodology for clinical trials has allowed investigators to better demonstrate the value of the AIT supported by evidence‐based medicine 6.…”

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confidence: 99%

Variation in allergen content in sublingual allergen immunotherapy with house dust mites

Benítez

Espinazo-Romeu

Camacho

et al. 2015

Allergy

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BackgroundAllergen immunotherapy is a treatment modality which can be applied using different vaccines. The aim of this study was to quantify and compare the allergen content of different house dust mites (HDM)’ sublingual treatments and to review the evidence on their efficacy.MethodsFive sublingual allergen immunotherapy (SLIT) products were ordered and purchased at an ordinary pharmacy and masked for blinding before the study was started. Detection of Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens Der p 1, Der f 1, Der p 2 and Der f 2 was carried out by immunoblotting and fluorescent multiplex. A literature search for meta‐analyses and systematic reviews that included SLIT‐HDM products was performed.ResultsDer p 1 concentrations ranged from 0.6 to 14.5 μg/ml; similar figures were found for Der f 1 that ranged from 0.2 to 12.4 μg/ml. Der p 2+ Der f 2 ranged from 0.2 to 1.5 μg/ml. Data on efficacy are scarce for most of the five products.ConclusionsSubstantial variations regarding allergen content were found among these five SLIT‐HDM products. Therefore, it can be necessary to guarantee the quality of the SLIT‐HDM products and to demonstrate their effectiveness before they are marketed. It seems necessary, for the moment, to take into account these characteristics of the products before prescribing.

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“…Component-resolved diagnosis (CRD) allows the evaluation of the individual sensitization pattern to environmental allergens (25,26). Nasal hyper-reactivity (NHR) can be diagnosed (27).…”

Section: Current Challenges Of Allergies and Chronic Respiratory Disementioning

confidence: 99%

European Symposium on Precision Medicine in Allergy and Airways Diseases: Report of the European Union Parliament Symposium (October 14, 2015)

Muraro

Fokkens²,

Pietikäinen

et al. 2016

Allergy

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Olive, grass or both? Molecular diagnosis for the allergen immunotherapy selection in polysensitized pollinic patients

Abstract: The diagnostic accuracy of the recombinant allergen-specific IgE test could help to improve the selection of specific-allergen immunotherapy in polysensitized patients.

Cited by 53 publications

References 24 publications

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence

Variation in allergen content in sublingual allergen immunotherapy with house dust mites

European Symposium on Precision Medicine in Allergy and Airways Diseases: Report of the European Union Parliament Symposium (October 14, 2015)

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