Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging

Yuan, Yue; Zhang, Jia; An, Linna; Cao, Qinjingwen; Ruan, Wenquan; Liang, Gaolin

doi:10.1016/j.biomaterials.2014.05.071

Cited by 37 publications

(30 citation statements)

References 34 publications

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“…Recently, researchers have found that some specific molecules used as targeting agents, such as carbohydrate, 10 folic acid, 11,12 transferrin, 13,14 and some peptides, 15,16 could be modified onto the surface of NPs and achieve active targeting therapy with high specificity, selectivity, and affinity through coupling targeting molecules with their specific receptor expressed on the cell surface.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Zhao¹,

Li²,

Shi³

et al. 2014

IJN

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Nanoparticles (NPs) which target specific agents could effectively recognize the target cells and increase the stability of chemical agents by encapsulation. As such, NPs have been widely used in cancer treatment research. Recently, over 90% of treatment failure cases in patients with metastatic cancer were attributed to resistance to chemotherapy. Surface-exposed glucose-regulated protein of 78 kDa (GRP78) is expressed highly on many tumor cell surfaces in many human cancers and is related to the regulation of invasion and metastasis. Herein, we report that NPs conjugated with antibody against GRP78 (mAb GRP78-NPs) inhibit the adhesion, invasion, and metastasis of hepatocellular carcinoma (HCC) and promote drug delivery of 5-fluorouracil into GRP78 high-expressed human hepatocellular carcinoma cells. Our new findings suggest that mAb GRP78-NPs could enhance drug accumulation by effectively transporting NPs into cell surface GRP78-overexpressed human hepatocellular carcinoma cells and then inhibit cell proliferation and viability and induce cell apoptosis by regulating caspase-3. In brief, mAb GRP78-NPs effectively inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery.

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Section: Introductionmentioning

confidence: 99%

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Zhao¹,

Li²,

Shi³

et al. 2014

IJN

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“…Qdots exhibit extremely bright fluorescence and narrow excitation and emission spectra, including in the NIR range, and thus allow for multi-channel imaging. Qdots have been extensively used for deep tissue imaging, reviewed elsewhere [310–313]; long-circulating Qdots have been useful for vasculature mapping, while molecularly targeted Qdots [314,315] have applications in selectively labeling circulating immune cell populations [316] and sensitively detecting cancer cells [317]. The lack of Qdot biodegradability increases their risk for toxicity, yet recent reports show positive safety profiles in non-human primates [318,319].…”

Section: The Nuts and Bolts Of Ivm Nanoparticle Imagingmentioning

confidence: 99%

Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior

Miller

Weissleder

2017

Advanced Drug Delivery Reviews

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Therapeutic nanoparticles (NPs) can deliver cytotoxic chemotherapeutics and other drugs more safely and efficiently to patients; furthermore, selective delivery to target tissues can theoretically be accomplished actively through coating NPs with molecular ligands, and passively through exploiting physiological “enhanced permeability and retention” features. However, clinical trial results have been mixed in showing improved efficacy with drug nano-encapsulation, largely due to heterogeneous NP accumulation at target sites across patients. Thus, a clear need exists to better understand why many NP strategies fail in vivo and not result in significantly improved tumor uptake or therapeutic response. Multicolor in vivo confocal fluorescence imaging (intravital microscopy; IVM) enables integrated pharmacokinetic and pharmacodynamic (PK/PD) measurement at the single-cell level, and has helped answer key questions regarding the biological mechanisms of in vivo NP behavior. This review summarizes progress to date and also describes useful technical strategies for successful IVM experimentation.

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“…With functional -NH2 and -SH groups on their surfaces, 1-NPs could be facilely conjugated with NIRemitting CdTe/CdS QDs and Mal-FA to synthesize oligomeric/inorganic hybrid nanoparticles 1-NPsQDs-FA. These nanoparticles have shown excellent targeting property to FR-expressing tumor cells in vitro and were successfully applied to selectively imaging FR overexpressing tumors in vivo 133 .…”

Section: Fig12: Structure Of Few Folate Conjugatesmentioning

confidence: 99%

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2016

IJPSR

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Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging

Cited by 37 publications

References 34 publications

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78

Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior

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