Oligoclonal immunoglobulin M in cerebrospinal fluid from multiple sclerosis patients

Keir, Geoff; Walker, Rodney W.H.; Thompson, E J

doi:10.1016/0022-510x(82)90034-x

Cited by 22 publications

(3 citation statements)

References 9 publications

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“…An obvious discordance exists between the frequency of IgM oligoclonal banding (62 and 74%, respectively, according to Sharief et al, 1990 andKeir et al, 1982), and the frequencies of IgM ITS, whatever the mathematical calculation used. This discordance was clearly djs-cussed by Sharief et al (1990); Sharief and Thompson, (1992) who reported no significant correlation between IgM 0.B.…”

Section: Igm Itsmentioning

confidence: 99%

Frequency and relevance of IgM intrathecal synthesis in multiple sclerosis

Reboul

Lambin

Gervais

et al. 1995

Euro J of Neurology

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Using a new ELISA method we have measured the IgM concentration in the serum and the cerebrospinal fluid CSF from 110 neurological patients. Among there, 41 had multiple sclerosis (MS), 48 other inflammatory diseases (OID), including 30 AIDS, and 21 non-inflammatory neurological diseases (NID). A highly significant correlation was established between results with native IgM and the dithiothreitol reduced IgM. An intrathecal synthesis (ITS) of IgM was detected using the CSF IgM/CSF albumin ratio, the IgM index and a quantitative formula in 33 patients: nine MS, 23 OID (including 18 AIDS) and one NID. The frequency of IgM ITS was 22% in MS patients, 48% in the OID (60% in AIDS) and 5% in the NID groups. This ITS was not impaired by an increase in serum IgM concentration or by a blood-CSF barrier damage. These facts confirm that intrathecal immunity is not a "steady-state" related to the general immunity but a specific response restricted to the central nervous system. Conversely, CSF IgM increase and IgM ITS were closely related (p < 10(-6) ). In addition, IgM ITS and IgG ITS were found to be highly correlated in OID, especially in AIDS patients: such correlation was not observed in the MS group. No significant correlations were observed between IgM ITS and any of the clinical parameters in MS patients. These results suggest the probable specificity of IgM ITS in MS patients.

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Section: Igm Itsmentioning

confidence: 99%

Frequency and relevance of IgM intrathecal synthesis in multiple sclerosis

Reboul

Lambin

Gervais

et al. 1995

Euro J of Neurology

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“…Virus isolation, serology, direct demonstration of viral agents from serum and CSF banding (Kier, Walker & Thompson, 1982;Thompson & Johnson, 1982;Timbury, 1978;Walker, Klein & Thompson, 1983) all represent increasing levels of sophistication in demonstrating not only viral infection but CNS involvement. One difficulty with most of these methods is the relatively late presentation to major centres for investigation following the viral illness (as with our cases) and therefore the problem of assessing the significance of the viral infection.…”

Section: Discussionmentioning

confidence: 99%

Viruses, Neurodevelopmental Disorder and Childhood Psychosis

Nunn¹,

Lask

Cohen

1986

Child Psychology Psychiatry

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Four cases are described of prepubertal boys in whom the convergence of neurodevelopmental disorder, viral infection and psychosis seemed more than coincidental. Review of the literature highlights the possibility that viral infection of the central nervous system may play a contributory role in childhood psychosis. Whilst it is essential to avoid a reductionist stance when investigating these difficult conditions, the emergence of potent anti-viral treatments and sophisticated methods of identifying the presence of viral infection should encourage us to consider more carefully the relevance of viruses in childhood psychosis.

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“…achtziger Jahre nur vereinzelt berichtet worden [13][14][15]. Verschiedene Methoden zum Nachweis von oligoklonalem IgM sind erst in der ersten Hälfte der neunziger Jahre an größeren Patienten-Kollektiven evaluiert worden: (a) Elektrophoretische Trennung von Liquor und nachfolgende Immunfixation mit Peroxidase-markierten anti-IgM-Antikörpern sowie Verstärkung der Antigen-Antikörpei-Reaktion durch Glutaraldehyd [16].…”

Section: Diskussionunclassified

Nachweis von systemischem und lokal synthetisiertem oligoklonalem IgM mittels isoelektrischer Fokussierung

Withold¹

1997

LaboratoriumsMedizin

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Oligoclonal immunoglobulin M in cerebrospinal fluid from multiple sclerosis patients

Cited by 22 publications

References 9 publications

Frequency and relevance of IgM intrathecal synthesis in multiple sclerosis

Frequency and relevance of IgM intrathecal synthesis in multiple sclerosis

Viruses, Neurodevelopmental Disorder and Childhood Psychosis

Nachweis von systemischem und lokal synthetisiertem oligoklonalem IgM mittels isoelektrischer Fokussierung

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