1986
DOI: 10.1111/j.1469-7610.1986.tb00621.x
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Viruses, Neurodevelopmental Disorder and Childhood Psychosis

Abstract: Four cases are described of prepubertal boys in whom the convergence of neurodevelopmental disorder, viral infection and psychosis seemed more than coincidental. Review of the literature highlights the possibility that viral infection of the central nervous system may play a contributory role in childhood psychosis. Whilst it is essential to avoid a reductionist stance when investigating these difficult conditions, the emergence of potent anti-viral treatments and sophisticated methods of identifying the prese… Show more

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Cited by 20 publications
(4 citation statements)
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References 31 publications
(17 reference statements)
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“…If obstetric complications are a true risk factor, there is no reason to suppose that this might not be true for other cerebral insults if sustained during this critical period of early brain development. Childhood head injury and encephalitides, for example, also seem to be occasional risk factors for schizophrenia (Nunn et al 1986;Wilcox & Nasrallah, 1987), as well as being events with demonstrable radiological sequelae such as non-progressive ventricular enlargement (Meyers et al 1983).…”
Section: Genes Environment and Brain Developmentmentioning
confidence: 99%
“…If obstetric complications are a true risk factor, there is no reason to suppose that this might not be true for other cerebral insults if sustained during this critical period of early brain development. Childhood head injury and encephalitides, for example, also seem to be occasional risk factors for schizophrenia (Nunn et al 1986;Wilcox & Nasrallah, 1987), as well as being events with demonstrable radiological sequelae such as non-progressive ventricular enlargement (Meyers et al 1983).…”
Section: Genes Environment and Brain Developmentmentioning
confidence: 99%
“…The possibility of viral encephalitis also should not be ignored. Nunn et al 19 reported four cases of childhood psychosis associated with viral encephalitis, but all showed evidence of infection or neurodevelopmental abnormalities. There was no such association in our patient.…”
Section: Discussionmentioning
confidence: 99%
“…20 Viral disease is considered to be an additional or independent cause. 21 Some theories suggest that autistic child's cognitive and emotional states, which are biologically determined, evoke a response in the caregivers which disrupts parental boding. Psychodynamic theory emphasizes the role of interpersonal factors as both the cause and the effect of autism.…”
Section: Etiological Modelsmentioning
confidence: 99%