Oligochitosan as a potential anti-acne vulgaris agent: combined antibacterial effects against Propionibacterium acnes

Kim, Song-Hee; Eom, Sung‐Hwan; Yu, Daeung; Lee, Myung-Suk; Kim, Young‐Mog

doi:10.1007/s10068-017-0118-y

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…The MICs were the lowest concentrations of the crude extract that inhibited visual growth after incubating aerobic bacteria for 18 h and anaerobic bacteria for 48 h [23]. The MICs of SMYEE were determined by using the two-fold serial dilution method employing 96-well flat-bottomed microtitration plates inoculated with C. acnes strains at a final concentration of 1.0 × 10 5 colony-forming units (CFU)/mL.…”

Section: Minimum Inhibitory Concentrations (Mic) and Minimum Bactericmentioning

confidence: 99%

“…After incubation, the microtitration plates were read visually at an optical density of 600 nm (OD 600 ), and the concentration of the chitosan-phytochemical conjugate that exhibited no turbidity was recorded as the MIC. MBCs were the lowest concentration to kill an initial bacterial inoculum by ≥99.9%; they can be determined from broth dilution MIC tests by sub-culturing to agar plates [23].…”

Section: Minimum Inhibitory Concentrations (Mic) and Minimum Bactericmentioning

confidence: 99%

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Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

et al. 2020

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Acne vulgaris is a chronic inflammatory condition of skin sebaceous follicles. To explore its effects on acne vulgaris, we investigated the antibacterial and anti-inflammatory activities of Sargassum miyabei Yendo (a brown alga) ethanolic extract (SMYEE) on Cutibacterium acnes (C. acnes)-stimulated inflammatory responses, both in vivo and in vitro. To induce inflammation in vivo, C. acnes was intradermally injected into the dorsal skin of mice, to which SMYEE was applied. The antimicrobial activity of SMYEE was evaluated by the determination of minimum inhibitory concentrations (MICs). To explore in vitro anti-inflammatory effects, HaCaT cells were stimulated with C. acnes after treatment with SMYEE. The levels of IL-8 and the underlying molecular effects in C. acnes-stimulated HaCaT cells were assessed by enzyme-linked immunosorbent assay, Western blotting, and an electrophoretic mobility shift assay. Mouse skin lesions improved after treatment with SMYEE (50 μg/mouse). Neutrophil infiltration was significantly reduced in SMYEE-treated compared to SMYEE-untreated skin lesions. SMYEE reversed the C. acnes-induced increase in IL-8 levels in HaCaT cells and suppressed dHL-60 cell migration. SMYEE also inhibited C. acnes-induced phosphorylation of the extracellular signal-regulated kinase and inhibited activator protein-1 signaling. SMYEE may be a useful treatment for C. acnes-induced acne vulgaris.

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Section: Minimum Inhibitory Concentrations (Mic) and Minimum Bactericmentioning

confidence: 99%

Section: Minimum Inhibitory Concentrations (Mic) and Minimum Bactericmentioning

confidence: 99%

Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

et al. 2020

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“…The liquid for the bacterial culture of P. acnes ATCC 11827 refers to the research by Kim et al (2017). The liquid saline medium used was 0.85% physiological NaCl.…”

Section: Bacterial Culturementioning

confidence: 99%

Characteristics and activity of chitosan from mud crab shells on acne bacteria: Staphylococcus aureus, S. epidermidis and Propionibacterium acnes

et al. 2023

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Abstract. Luthfiyana N, Bija S, Anwar E, Laksmitawati DE, Risalinda GL. 2022. Characteristics and activity of chitosan from mud crab shells on acne bacteria: Staphylococcus aureus, S. epidermidis and Propionibacterium acnes. Biodiversitas 23: 6645-6651. Chitosan is a product of chitin deacetylation, which has the potential to act as acne bacteria. The study aimed to determine the characteristics and activity of chitosan from mud crab shells on acne bacteria, i.e., Staphylococcus aureus FNCC 0047, Staphylococcus epidermidis FNCC 0048 and Propionibacterium acnes ATCC 11827. The research used a descriptive method for analyzing the quality of chitosan and antibacterial activity using analysis of variants at a 95% confidence interval with one factor, while the addition of chitosan as much as 0.25%; 0.5%; 0.75%; and 1% with three replications. The results showed that the value of deacetylation degree (DD) was 76%. The morphology of chitosan shows irregular, wavy, porous shapes and contains several elements: C, O, Ca, and Al. The antibacterial activity of chitosan at concentrations of 0.25%, 0.5%, 0.75%, and 1% showed an inhibition zone of S. aureus (9.5±0.71 mm, 10±0 mm, 11±0 mm, 13.5±0.71 mm), S. epidermidis (9±0 mm, 10±0 mm, 11±0 mm, 12.5±0.71 mm), and P. acnes (28.5±0.7 mm, 28.5±0.7 mm, 31±5.56 mm, 34.5±6.36 mm). The concentration of 1% gives the effectiveness in inhibiting the growth of acne bacteria. This study concludes that chitosan from mud crab shells could be the potential as an anti-acne.

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“…Additionally, many reports have demonstrated the antibacterial effects and antifungal effects of chitosan oligosaccharide. Chitosan oligosaccharide (10 kDa) had the highest antimicrobial effect with minimum inhibitory concentration values of 32–64 μg/mL on Propionibacterium acnes [ 24 ]. In addition, low-molecular-weight chitosan oligosaccharide inhibited bacterial activity, biofilm formation and hemolytic activity of Staphylococcus aureus [ 209 ].…”

Section: Potential Applications Of Chitin and Chitosan Oligosacchamentioning

confidence: 99%

“…Chitosan oligosaccharide has the degree of polymerization of <55 and molecular weight of <10 kDa [ 22 ]. Chitosan oligosaccharides have a variety of biomedical applications such as drug delivery system [ 20 ], functional food [ 23 ], as well as the drug against acne vulgaris [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Satitsri

Muanprasat

2020

Molecules

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Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.

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Oligochitosan as a potential anti-acne vulgaris agent: combined antibacterial effects against Propionibacterium acnes

Cited by 11 publications

References 28 publications

Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation

Characteristics and activity of chitosan from mud crab shells on acne bacteria: Staphylococcus aureus, S. epidermidis and Propionibacterium acnes

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

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