Olfactory signaling via trace amine-associated receptors

Dewan, Adam

doi:10.1007/s00441-020-03331-5

Cited by 23 publications

(30 citation statements)

References 92 publications

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“…While the expression of TAAR5 in the olfactory sensory neurons and the olfactory bulb is well established [4,5], the expression of TAAR5 in the brain was also described previously by different approaches. When the TAAR5 receptor was first reported as PNR, its expression was evidenced by Northern blot hybridization in the different areas of the human brain, including the amygdala, hippocampus, caudate nucleus, thalamus, and hypothalamus.…”

Section: Discussionmentioning

confidence: 70%

“…High-throughput transcriptomic studies described here also provided evidence for the wide distribution of TAAR5 expression in the adult human brain, particularly in the limbic brain areas involved in olfactory information processing and responsible for emotional regulation. The unique localization of TAAR5 in the olfactory epithelium and the olfactory bulb [1,3,4,31] as well in the downstream "emotional" limbic areas receiving input from the olfactory bulb, such as the frontal cortex, the amygdala, the hippocampus, the nucleus accumbens, the thalamus, the hypothalamus, suggest the intriguing possibility that "olfactory" TAAR5-mediated brain circuitry may represent a new type of neurotransmitter system involved in the transmission of innate odors into emotional behavioral responses [5] and adult neurogenesis [6]. Expression of TAAR5 mRNA was also detected in various structures of the basal ganglia, the cerebellum, the substantia nigra, and the white matter.…”

Section: Discussionmentioning

confidence: 99%

“…In mice, 14 of the 15 TAARs (except TAAR1) are expressed in the main olfactory epithelium and project to the olfactory bulb glomeruli, which express the appropriate TAAR receptor. In humans, five out of six functional TAARs (TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) are believed to serve similar olfactory functions [4]. However, there is recent evidence from the knockout mouse model that at least one member of this family, TAAR5, is expressed also in the limbic areas of the brain receiving projection from the olfactory system and involved in the regulation of monoamine transmission, emotional behaviors, and adult neurogenesis [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis

Vaganova

Murtazina

Shemyakova

et al. 2021

IJMS

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Trace amine-associated receptors (TAAR) recognize organic compounds, including primary, secondary, and tertiary amines. The TAAR5 receptor is known to be involved in the olfactory sensing of innate socially relevant odors encoded by volatile amines. However, emerging data point to the involvement of TAAR5 in brain functions, particularly in the emotional behaviors mediated by the limbic system which suggests its potential contribution to the pathogenesis of neuropsychiatric diseases. TAAR5 expression was explored in datasets available in the Gene Expression Omnibus, Allen Brain Atlas, and Human Protein Atlas databases. Transcriptomic data demonstrate ubiquitous low TAAR5 expression in the cortical and limbic brain areas, the amygdala and the hippocampus, the nucleus accumbens, the thalamus, the hypothalamus, the basal ganglia, the cerebellum, the substantia nigra, and the white matter. Altered TAAR5 expression is identified in Down syndrome, major depressive disorder, or HIV-associated encephalitis. Taken together, these data indicate that TAAR5 in humans is expressed not only in the olfactory system but also in certain brain structures, including the limbic regions receiving olfactory input and involved in critical brain functions. Thus, TAAR5 can potentially be involved in the pathogenesis of brain disorders and represents a valuable novel target for neuropsychopharmacology.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis

Vaganova

Murtazina

Shemyakova

et al. 2021

IJMS

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“…TMA is abundant in the urine of mice and shows ca. 30-fold higher levels in males than females 42 . This amine is a metabolite of gut microbiota 43 , and it is sexually dimorphic because females oxidize it in the liver 11 .…”

Section: Discussionmentioning

confidence: 87%

Pheromones that correlate with reproductive success in competitive conditions

Luzynski

Nicolakis

Marconi

et al. 2021

Sci Rep

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The major urinary proteins (MUPs) of house mice (Mus musculus) bind and stabilize the release of pheromones and other volatile organic compounds (VOCs) from urinary scent marks, which mediate chemical communication. Social status influences MUP and VOC excretion, and the urinary scent of dominant males is attractive to females. Urinary pheromones influence the sexual behavior and physiology of conspecifics, and yet it is not known whether they also affect reproductive success. We monitored the excretion of urinary protein and VOCs of wild-derived house mice living in large seminatural enclosures to compare the sexes and to test how these compounds correlate with reproductive success. Among males, urinary protein concentration and VOC expression correlated with reproductive success and social status. Territorial dominance also correlated with reproductive success in both sexes; but among females, no urinary compounds were found to correlate with social status or reproductive success. We found several differences in the urinary protein and volatile pheromones of mice in standard cages versus seminatural enclosures, which raises caveats for conventional laboratory studies. These findings provide novel evidence for chemical signals that correlate with male reproductive success of house mice living in competitive conditions.

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“…Thereby, they particularly focus on the neofunctionalization of these receptors from immune pathogen sensors to olfactory chemosensors. The current knowledge on the olfactory trace amine-associated receptors is comprehensively reviewed in the contribution of Dewan ( 2021 ). This review also discusses whether trace amine associated receptors represent a unique subsystem within the main olfactory system.…”

mentioning

confidence: 99%