Olfactory Neuroblastoma in Dogs and Cats – a Histological and Immunohistochemical Analysis

Brosinski, Katrin; Janik, Dirk; Bomhard, Wolf von; Schmahl, W.

doi:10.1016/j.jcpa.2011.06.002

Cited by 29 publications

(70 citation statements)

References 30 publications

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“…Reports on the application of these classification systems of ONBs in animals are limited. However, due to the similarities between tumours in man and domesticated animals, both classification systems appear to be applicable and were utilized in a few studies on ONB in animals, which have been conducted recently …”

Section: Pathological Grading and Clinical Stagingmentioning

confidence: 99%

Of mice and men: olfactory neuroblastoma among animals and humans

Lubojemska

Borejko

Czapiewski

et al. 2014

Vet Comparative Oncology

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Olfactory neuroblastoma (ONB) is a rare tumour of nasal cavity and paranasal sinuses that arises from the olfactory neuroepithelium and has unpredictable clinical course. As the sense of smell is phylogenetically one of the first senses and olfactory neuroepithelium is evolutionary conserved with striking similarities among different species, we performed an extensive analysis of the literature in order to evaluate the similarities and differences between animals and humans on the clinical, morphological, immunohistochemical, ultrastructural and molecular level. Our analysis revealed that ONB was reported mainly in mammals and showed striking similarities to human ONB. These observations provide rationale for introduction of therapy modalities used in humans into the veterinary medicine. Animal models of neuroblastoma should be considered for the preclinical studies evaluating novel therapies for ONB.

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Section: Pathological Grading and Clinical Stagingmentioning

confidence: 99%

Of mice and men: olfactory neuroblastoma among animals and humans

Lubojemska

Borejko

Czapiewski

et al. 2014

Vet Comparative Oncology

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“…7 The most common signs related to the central nervous system and changes in demeanour (aggression, anxiety, apathy or excitation) predominated over seizures. 7 The most common signs related to the central nervous system and changes in demeanour (aggression, anxiety, apathy or excitation) predominated over seizures.…”

mentioning

confidence: 99%

Long‐term control of olfactory neuroblastoma in a dog treated with surgery and radiation therapy

Gumpel¹,

Moore²,

Simpson³

et al. 2017

Aust Veterinary J

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“…17 Calcification and necrosis are infrequently present in canine esthesioneuroblastomas. 2 In combination, these features are of limited diagnostic value. Unfortunately, precise immunohistologic differentiation is hampered by the inconsistent expression pattern of neuroglial markers in both tumor types.…”

Section: Discussionmentioning

confidence: 99%

Metastasizing Esthesioneuroblastoma in a Dog

et al. 2014

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A 7-year-old Afghan hound presented with a history of disorientation, loss of vision, and seizures. Magnetic resonance imaging helped identify a mass at the level of the main olfactory bulb that compressed and displaced adjacent tissues in the cribriform plate into the nasal cavity and nasopharynx. Bony structures were osteolytic. After removing almost 80% of the mass, the tumor recurred a few months later. Due to severe respiratory distress and subsequent to an ultrasound diagnosis of a liver tumor, the dog was euthanized. In addition to the nasal mass, a single nodule in the liver and multiple nodules in the lung were present. All masses had similar cell morphology and were diagnosed as metastasizing esthesioneuroblastoma. The neoplastic cells expressed neuron-specific enolase and chromogranin A, and a few cells within the nasal mass were positive for cytokeratin. This is the first description of a canine esthesioneuroblastoma with distant metastases.

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Olfactory Neuroblastoma in Dogs and Cats – a Histological and Immunohistochemical Analysis

Cited by 29 publications

References 30 publications

Of mice and men: olfactory neuroblastoma among animals and humans

Of mice and men: olfactory neuroblastoma among animals and humans

Long‐term control of olfactory neuroblastoma in a dog treated with surgery and radiation therapy

Metastasizing Esthesioneuroblastoma in a Dog

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