Long‐term control of olfactory neuroblastoma in a dog treated with surgery and radiation therapy

Abstract

The dog survived 20 months after diagnosis. Although olfactory neuroblastoma is a rare tumour in dogs, aggressive local therapy may allow for prolonged survival, even when the tumour is advanced.

What is your diagnosis? Fine‐needle aspirate from a nasal mass in a dog

“…Both are locally infiltrative and can involve invasion of the brain, and both have the potential for widespread metastases, though it has been rarely reported in ON with a few more individual cases reported for NEC . Longer term control has been achieved using a combination of surgery and radiation with survival times up to 20 months reported in an ON case .…”

In this issue – July 2017

“…2 These rare tumours originate from neuroendocrine olfactory cells and generally have reported survival times of between 2 and 6.7 months. 2 These rare tumours originate from neuroendocrine olfactory cells and generally have reported survival times of between 2 and 6.7 months.…”

“…A case report describes the outcome of a 44-kg Alaskan malamute that was treated with surgery and radiation therapy for an olfactory neuroblastoma. 2 These rare tumours originate from neuroendocrine olfactory cells and generally have reported survival times of between 2 and 6.7 months. The authors show MRI scans of the tumour and report the extensive postoperative radiation treatment.…”

Clinical outcomes, ultrastructure and immunohistochemical features of canine high‐grade olfactory neuroblastoma

“…Intranasal neoplasia, regardless of type, tends to be difficult to resect and is frequently locally aggressive with limited therapeutic options . In general, nasal neoplasms are treated with radiation therapy, which has been demonstrated to improve clinical outcomes in the few reports published . ONB, also called esthesioneuroblastoma, is a nasal tumour that occurs in dogs and humans and can span the cribriform plate to occupy intranasal and intracranial compartments .…”

“…In humans, ONB is generally treated with surgery followed by radiotherapy, however, there is increasing evidence that use of adjunct chemotherapy improves clinical outcome . In canine patients, radiotherapy is often recommended as adjuvant therapy post‐debulking or as the primary modality in nasal neoplasms . There is limited information regarding long‐term survival in dogs with ONB treated with radiation, with published case reports reporting a wide range of survival times (3‐20 months) …”