Olfactory mucosa: a rich source of cell therapy for central nervous system repair

Duan, Da; Lu, Ming

doi:10.1515/revneuro-2014-0065

Cited by 33 publications

(35 citation statements)

References 91 publications

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“…Among these are olfactory neurons (ON) that are able to regenerate continuously throughout adult life. This regenerative capacity is atributed to olfactory stem cells and supporting cells of OM, together promoting axonal regeneration [73]. In addition to the bipolar ON or olfactory neurosensory cells, several cell types can be identiied in the OM: horizontal basal stem cells (HBCs) and globular basal stem cells (GBCs) in the olfactory epithelium, MSCs in the lamina propria, olfactory ensheathing cells (OECs) and support cells ( Figure 5).…”

Section: General Featuresmentioning

confidence: 99%

Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury

Alvites¹,

Santos²,

ProençaVarejão³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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The peripheral nerve injury after trauma is a common occurrence in both human and veterinary medicine and has severe consequences for the survival and quality of life of the patients. Despite the continuous eforts and the creation of diverse medical and surgical techniques, the harmful efects of this type of injury are far from being overcome. Regenerative medicine has been growing in the scientiic milieu as a new therapeutic approach for diferent situations. Among the cell-based therapies explored, the mesenchymal stem cells are evidenced by their features, versatility and potential applications. The olfactory mucosa mesenchymal stem cells, components of the olfactory system and identiied in the lamina propria, were newly identiied and are still undergoing characterization, appearing as a new promise in the regenerative therapy of several tissues but with special emphasis on the nervous system in general and the peripheral nervous system in particular, for which they appear to have special regenerative aptitude.

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Section: General Featuresmentioning

confidence: 99%

Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury

Alvites¹,

Santos²,

ProençaVarejão³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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“…Em associação aos placó-dios está o tecido pré-neural que posteriormente formará o bulbo olfatório, local responsável pela percepção do olfato (Carlson 1996). Os neurônios olfativos localizados no EO possuem capacidade de regeneração diferenciada que perdura durante a vida adulta, indicando que parte deste tecido é constituída por células-tronco progenitoras (Duan & Lu 2015). A maioria das células-tronco presentes nesse tecido se origina do ectoderma e são multipotentes.…”

Section: Tópico De Interesse Geralunclassified

“…Recentemente foram publicadas pesquisas com uma nova abordagem para o uso das células-tronco do epitélio olfatório, no tratamento de dor neuropática e terapia gê-nica em neoplasias. Esses dados nos revelam um grande potencial de plasticidade e aplicabilidade dessas células (Duan & Lu 2015).…”

Section: Aplicações Terapêuticas Das Células-tronco Do Epitélio Olfatunclassified

“…O primeiro que pode ser citado é que a garantia de segurança do uso destas células foi comprovada somente em transplantes autólogos (Goni et al 2014), ficando a ressalva da utilização das CTEO em transplantes não autólogos. O segundo fator de risco importante é a formação de tumores em animais e humanos após o transplante celular (Seminatore et al 2010, Duan & Lu 2015. Por isso, o controle proliferativo, de sobrevivência, migração e diferenciação após transplante são pontos que precisam ser melhores elucidados.…”

Section: Aplicações Em Células Tumoraisunclassified

“…No epitélio olfatório estão localizadas as células basais horizontais e globosas, bem como receptores maduros e imaturos de neurônios. A lâmina basal possui em sua composição células da glia (macroglia ou glia radial) e as célu-las-tronco mesenquimais (Duan & Lu 2015).…”

Section: Introductionunclassified

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Células-tronco derivadas do epitélio olfatório: perspectivas terapêuticas na medicina veterinária

et al. 2016

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ABSTRACT.-Mazzarella R., Garnica T.K., Roballo K. The olfactory epithelium (OE) is a promising source of stem cells (OESC) for therapeutic use in veterinary and human medicine, especially in diseases correlated with the peripheral (spinal cord) and central (brain and brainstem) nervous system (CNS), because of its ability to differentiate into neurons, astrocytes and oligodendrocytes cells. In humans, OESC has been used primarily in therapeutic trials for degenerative diseases such as Alzheimer and Parkinson. In animals, the frequency of corresponding cases of chronic or acute neurodegenerative diseases is very low, because of the difficulty of a definitive diagnosis; thus, the focus of cell therapy research are mostly mechanical spinal cord injuries. Due to the lack of normalization and selection of the best methodologies for comparative studies, this review aims to analyze recent reports on the potential use of stem cells from the olfactory epithelium in cell therapies and to discuss the main challenges and future prospects in veterinary medicine.INDEX TERMS: Olfactory epithelium, stem cell, spinal cord therapies, veterinary medicine.¹ Recebido em 5 de fevereiro de 2016.Aceito para publicação em 3 de maio de 2016.

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Functional Consequences of Keratan Sulfate Sulfation in Electrosensory Tissues and in Neuronal Regulation

Melrose

2019

Adv. Biosys.

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Keratan sulfate (KS) is a functional electrosensory and neuro‐instructive molecule. Recent studies have identified novel low sulfation KS in auditory and sensory tissues such as the tectorial membrane of the organ of Corti and the Ampullae of Lorenzini in elasmobranch fish. These are extremely sensitive proton gradient detection systems that send signals to neural interfaces to facilitate audition and electrolocation. High and low sulfation KS have differential functional roles in song learning in the immature male zebra song‐finch with high charge density KS in song nuclei promoting brain development and cognitive learning. The conductive properties of KS are relevant to the excitable neural phenotype. High sulfation KS interacts with a large number of guidance and neuroregulatory proteins. The KS proteoglycan microtubule associated protein‐1B (MAP1B) stabilizes actin and tubulin cytoskeletal development during neuritogenesis. A second 12 span transmembrane synaptic vesicle associated KS proteoglycan (SV2) provides a smart gel storage matrix for the storage of neurotransmitters. MAP1B and SV2 have prominent roles to play in neuroregulation. Aggrecan and phosphacan have roles in perineuronal net formation and in neuroregulation. A greater understanding of the biology of KS may be insightful as to how neural repair might be improved.

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Olfactory mucosa: a rich source of cell therapy for central nervous system repair

Cited by 33 publications

References 91 publications

Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury

Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury

Células-tronco derivadas do epitélio olfatório: perspectivas terapêuticas na medicina veterinária

Functional Consequences of Keratan Sulfate Sulfation in Electrosensory Tissues and in Neuronal Regulation

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