“…The life span of OSNs is relatively short, around 30 days in young mammals (Brann & Firestein, ), and so there is a need for continual neurogenesis in order to maintain a normal sense of smell. Harnessing the unusual neuroregenerative abilities of the olfactory system continues to be promoted as a therapeutic approach to the reversal of spinal cord injury and certain demyelinating conditions (Assinck, Duncan, Hilton, Plemel, & Tetzlaff, ; Ekberg & St John, ; Gladwin & Choi, ; Gomez et al, ; Yao et al, ). The olfactory mucosa (OM) represents a particularly attractive target for sourcing OECs for clinical transplantation, as it permits relatively noninvasive endoscopic harvesting from affected patients, healthy volunteers, or cadaveric specimens (Andrews, Poirrier, Lund, & Choi, ; Choi & Gladwin, ).…”