Oleuropin controls miR-194/XIST/PD-L1 loop in triple negative breast cancer: New role of nutri-epigenetics in immune-oncology

Hamed, Marwa M.; Handoussa, Heba; Hussein, Nada H.; Eissa, Reda A.; Abdel-Aal, Lobna K.; Tayebi, H.M. El

doi:10.1016/j.lfs.2021.119353

Cited by 21 publications

(11 citation statements)

References 51 publications

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“…MDA-MB-231 cells are ER, PR, and HER2-. MDA-MB-231 cells were cultured using our previous protocol ( Hamed et al, 2021 ). The cell line was cultured in a suitable culture media [high-glucose DMEM supplemented with 10% FBS and 1% penicillin/streptomycin in 10 cm Petri dishes (Gibco, United States)].…”

Section: Methodsmentioning

confidence: 99%

A cutting-edge immunomodulatory interlinkage between HOTAIR and MALAT1 in tumor-associated macrophages in breast cancer: A personalized immunotherapeutic approach

Amer

Eissa²,

Tayebi³

2022

Front. Mol. Biosci.

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Breast cancer (BC) is one of the most common cancers, accounting for 2.3 million cases worldwide. BC can be molecularly subclassified into luminal A, luminal B HER2-, luminal B HER2+, HER2+, and triple-negative breast cancer (TNBC). These molecular subtypes differ in their prognosis and treatment strategies; thus, understanding the tumor microenvironment (TME) of BC could lead to new potential treatment strategies. The TME hosts a population of cells that act as antitumorigenic such as tumor-associated eosinophils or pro-tumorigenic such as cancer-associated fibroblasts (CAFs), tumor-associated neutrophils (TANs), monocytic-derived populations such as MDSCs, or most importantly “tumor-associated macrophages (TAMs),” which are derived from CD14+ monocytes. TAMs are reported to have the pro-inflammatory phenotype M1, which is found only in the very early stages of tumor and is not correlated with progression; however, the M2 phenotype is anti-inflammatory that is correlated with tumor progression and metastasis. The current study focused on controlling the anti-inflammatory activity in TAMs of hormonal, HER2+, and TNBC by epigenetic fine-tuning of two immunomodulatory proteins, namely, CD80 and mesothelin (MSLN), which are known to be overexpressed in BC with pro-tumorigenic activity. Long non-coding RNAs are crucial key players in tumor progression whether acting as oncogenic or tumor suppressors. We focused on the regulatory role of MALAT1 and HOTAIR lncRNAs and their role in controlling the tumorigenic activity of TAMs. This study observed the impact of manipulation of MALAT1 and HOTAIR on the expression of both CD80 and MSLN in TAMs of BC. Moreover, we analyzed the interlinkage between HOTAIR and MALAT1 as regulators to one another in TAMs of BC. The current study reported an upstream regulatory effect of HOTAIR on MALAT1. Moreover, our results showed a promising use of MALAT1 and HOTAIR in regulating oncogenic immune-modulatory proteins MSLN and CD80 in TAMs of HER2+ and TNBC. The downregulation of MALAT1 and HOTAIR resulted in the upregulation of CD80 and MSLN, which indicates that they might have a cell-specific activity in TAMs. These data shed light on novel key players affecting the anti-inflammatory activity of TAMs as a possible therapeutic target in HER2+ and TNBC.

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Section: Methodsmentioning

confidence: 99%

A cutting-edge immunomodulatory interlinkage between HOTAIR and MALAT1 in tumor-associated macrophages in breast cancer: A personalized immunotherapeutic approach

Amer

Eissa²,

Tayebi³

2022

Front. Mol. Biosci.

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“…Cancer Seçme et al, 2016;Capo et al, 2017;Sherif, Al-Gayyar, 2018;Ruzzolini e al., 2018;;Nicolin et al, 2019;Torić et al, 2019;Przychodzen et al,2019a;Przychodzen et al, 2019b;Castejón et al, 2020;Leto et al, 2020;Asgharzade et al, 2021;Hamed et al, 2021;Ramírez-Expósito et al, 2021.…”

Section: Cholesterolmentioning

confidence: 99%

“…In a study by Hamed et al (2021), an oleuropein controlled the miR-194 / XIST / PD-L1 loop without triple negative breast cancer, representing a new nutriepigenetic in immunoncology. Sherif and Al-Gayyar (2018) reported that oleuropein potentiates the antitumor activity of cisplatin and can improve the side effect of its use by reducing the dose required to treat hepatocellular carcinoma (HCC), one of the most common tumors in the world and the leading cause of death from cancer.…”

Section: Hypertensionmentioning

confidence: 99%

Leaves of Olea europaea L. as a source of oleuropein: characteristics and biological aspects

Otero¹,

Lorini

Oliveira

et al. 2021

RSD

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Olive fruits, leaves and derived virgin oils are known to be good sources of polyphenols and other antioxidants that have recently received increasing interest. In addition, its derivatives are responsible for the bitter and spicy taste of green olive fruits and virgin olive oils. In the physiology of the olive plant, the enzymatic biotransformation of oleuropein is related to fruit ripening and the tissue-specific defense mechanism. The oleuropein is one of the main phenolic compounds identified in fruits and olive leaves. It has several pharmacological properties, including antioxidant, cardioprotective, anti-heterogeneous, neuropathic, anti-cancer and other effects. Oleuropein is slightly absorbed after oral administration and reaches a maximum plasma concentration, being widely distributed in various organs and tissues, including the heart, liver and brain. In view of recent studies on the use oleuropein obtained from olive leaves in the treatment and prevention of diseases, this work was carried out with the aim of compiling the main information available in the literature through this review.

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“…The tumor microenvironment (TME) is a complex milieu in which immune infiltration can activate or restrain tumor progression and metastasis, which forms the tumor immune microenvironment (TIME) [ 21 , 22 ]. Previous studies discovered that XIST and its downstream regulators were correlated with TIME and PD-L1 expression, and played critical roles in invasion and metastasis of cancers [ 16 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Pan-cancer analysis of LncRNA XIST and its potential mechanisms in human cancers

Han

Shi

et al. 2022

Heliyon

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Oleuropin controls miR-194/XIST/PD-L1 loop in triple negative breast cancer: New role of nutri-epigenetics in immune-oncology

Cited by 21 publications

References 51 publications

A cutting-edge immunomodulatory interlinkage between HOTAIR and MALAT1 in tumor-associated macrophages in breast cancer: A personalized immunotherapeutic approach

A cutting-edge immunomodulatory interlinkage between HOTAIR and MALAT1 in tumor-associated macrophages in breast cancer: A personalized immunotherapeutic approach

Leaves of Olea europaea L. as a source of oleuropein: characteristics and biological aspects

Pan-cancer analysis of LncRNA XIST and its potential mechanisms in human cancers

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