Pan-cancer analysis of LncRNA XIST and its potential mechanisms in human cancers

A lncRNA-disease association prediction model based on the two-step PU learning and fully connected neural networks

“…For example, lncRNA H19 has been shown to increase the HMGA2-mediated epithelial-mesenchymal transformation (EMT) in pancreatic ductal adenocarcinoma (PDAC) by antagonizing let-7, at least partially promoting PDAC cells [ 9 ]. In the future, lncRNA is expected to become a new biomarker to study the pathogenesis of diseases and guide disease treatment [ [10] , [11] , [12] , [13] , [14] ]. Therefore, it is of great significance to study the associations between lncRNA and diseases.…”