Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity

Leri, Manuela; Oropesa-Nuñez, Reiner; Canale, Claudio; Raimondi, Sara; Giorgetti, Sofia; Bruzzone, Elena; Bellotti, Vittorio; Stefani, Massimo; Bucciantini, Monica

doi:10.1016/j.bbagen.2018.03.023

Cited by 33 publications

(40 citation statements)

References 47 publications

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“…Another interesting aspect of the anti-cytotoxic action of OleA, in the contest of amyloydosis, was reported by Leri et al [130]. Using another amyloidogenic protein, a variant of human β2-microglobulin (β 2 m) [131][132][133] a 99 residue-long human protein belonging to the major histocompatibility complex class I (MHC I) associated with a familial form of systemic amyloidosis, they showed that it exhibited an enhanced amyloidogenic tendency to aggregate in vitro with respect to the wild-type protein.…”

Section: Oleuropein As Anti-amyloid Toolmentioning

confidence: 74%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

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Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.

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Section: Oleuropein As Anti-amyloid Toolmentioning

confidence: 74%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

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“…Therefore, in an additional set of experiments, we investigated the ability of the Aβ 42 aggregates grown in the presence of ARE (100 µg/mL) to interact with the cell membrane of exposed cells with respect to the aggregates grown in the absence of ARE. To this purpose, we performed confocal microscopy experiments using a polyclonal antibody raised against recombinant Aβ 42 and Alexa 488-conjugated CTX-B, a probe specific for the monosialotetrahexosylganglioside 1 (GM1), a common lipid raft marker widely reported as a key interaction site for amyloids [22, 25]. Aβ 42 fibrils interaction with GM1 was evaluated by FRET analysis (Fig.…”

Section: Resultsmentioning

confidence: 99%

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

Boubakri

Leri

Bucciantini

et al. 2019

Preprint

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27Allium roseum is an important medicinal and aromatic plant, specific to the North African flora 28 and a rich source of important nutrients and bioactive molecules including flavonoids and 29 organosulfur compounds whose biological activities and pharmacological properties are well known. 30 In the present study, the inhibition of amyloid beta protein toxicity by the ethanolic extract of this 31 plant is investigated for the first time. Preliminary biochemical analyses identified kaempferol and 32 Luteolin-7-o-glucoside as the more abundant phenolic compounds. The effects of A. roseum extract 33 (ARE) on amyloid beta-42 (Aβ 42 ) aggregation and aggregate cytotoxicity, were investigated by 34 biophysical (ThT assay, Dynamic light scattering and transmission electron microscopy) and cellular 35 assays (cytotoxicity, aggregate immunolocalization, ROS measurement and intracellular 36Ca 2+ imaging). The biophysical data suggest that ARE affects the structure of Aβ 42 peptide, inhibits 37 its polymerization, and interferes with the path of fibrillogenesis. The data with cultured cells shows 38 that ARE reduces Aß 42 aggregate toxicity by inhibiting aggregate binding to the cell membrane and 39 by decreasing both oxidative stress and intracellular Ca 2+ . Accordingly, ARE could act as a 40 neuroprotective factor against Aβ aggregate toxicity in Alzheimer's disease. 41 42 Alzheimer's disease. 3 44 1. Introduction 45 Alzheimer's disease (AD), the main cause of senile dementia, is a progressive 46 neurodegenerative disorder associated with cognitive impairment and loss of neuronal cells affecting 47 over 25 million people worldwide [1], thus representing a heavy economic burden and a major health 48problem. The pathology is characterized by the accumulation in the brain of amyloid-β peptide (Aβ) 49 and hyperphosphorylated tau protein mainly found as extracellular senile plaques and intracellular 50 neurofibrillary tangles, respectively [2]. Aβ oligomers overproduction caused by mutations in APP 51 and presenilins [3, 4] appears to be directly associated to cognitive dysfunction and neurodegeneration 52 in AD [5]. Accordingly, toxic Aβ oligomers production and/or interaction with nerve cells appear 53 useful targets to reduce neuronal cell dysfunction. Feart, Samieri [6] suggest that in most cases AD is 54 affected by a combination of genetic and environmental risk factors, including physical activity and 55 nutrition; in particular, increasing evidence indicates that diet plays an important role in AD. Several 56 studies have associated plant food (i.e., vegetables, fruits, legumes, and cereals) consumption to 57 reduced risk of AD [7, 8]. Moreover, traditional medicine is increasingly appreciated as a useful 58 approach to treat many illnesses, and large funds are invested to explore the therapeutic potential of 59 medicinal plants. Fortunately, the search of active compounds from nature prospers and the results 60 increasingly obtained confirm the need to better known the therapeutic potential of these natur...

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“…Animal studies showed a higher level of autophagy, while cell culture experiments suggest that probably oleuropein aglycon regulates mTOR protein [87]. Recent studies confirmed the activity of oleuropein aglycon against amyloid aggregation by modification of the conformational and biophysical properties of amyloid fibrils and of the cell bilayer surface properties at the same time, remodeling the aggregation and helping the association between the protein and the membrane [88]. In AD situation, it was observed various Aβ peptides in amyloid plaques were observed, characterized by N-terminal truncation.…”

Section: Oleuropein Aglyconmentioning

confidence: 93%

Olive Oil Phenols

Papanikolaou¹,

Melliou²,

Magiatis³

2019

Functional Foods

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Olive oils contain numerous substances that have a beneficial role in human health. Phenols are natural compounds that are present in extra-virgin olive oil (EVOO), and they are produced at the malaxation step of the olive oil production. The four most abundant phenols in EVOO are oleocanthal, oleacein, ligstroside aglycon, and oleuropein aglycon. These phenols exhibit significant biological effects in many diseases, participating in various cellular and biochemical processes. Oleocanthal can protect and prevent against the Alzheimer disease, demonstrates acute antiplatelet effects, which has a vital role against cancer, and can act like ibuprofen. Oleacein has antioxidant and anti-inflammatory activities and helps against atherosclerosis. Moreover, it acts as an antiaging factor and as a 5-lipoxygenase inhibitor. Ligstroside aglycon implicates to mechanisms against breast cancer, while oleuropein aglycon shows activities against the Alzheimer disease and breast cancer.

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Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity

Abstract: The data provided in the present article focus on OleA protection, featuring this polyphenol as a promising plant molecule useful against amyloid diseases.

Cited by 33 publications

References 47 publications

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

Olive Oil Phenols

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