Óleos essenciais como inibidores da acetilcolinesterase

Souza, Stefânia P. de; Valverde, Simone Sacramento; Silva, Raphael L. N. R. da; Lima, Keila S. C.; Lima, Antonio L. S.

doi:10.32712/2446-4775.2012.161

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…The hyperactivity in insects is associated to compounds that inhibit the acetylcholinesterase (AChE), which leads to a higher displacement and irritability, because this enzyme is related to the general coordination in the neuromuscular system (Abdelgaleil et al, 2009;Cordeiro et al, 2010;Kang et al, 2013; ). The α-pinene, as others terpenoids, has been reported to inhibit AChE activity (Viegas, 2003;Tsukamoto et al, 2005;Souza et al, 2012). That could explain the higher displacement observed in the treated insects of our study.…”

Section: Discussionsupporting

confidence: 46%

Varronia curassavica Jacq. (Boraginaceae) as an agroecological tool for coffee pest management

Andrade

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Coffee (Coffea sp.) is a crop of great relevance in agriculture. However, its productivity can be severely affected by the attack of pests, such as Leucoptera coffeella and Hypothenemus hampei. The coffee leaf miner, L. coffeella, is a key coffee pest in the Neotropics. The larvae feed on the parenchyma of coffee leaves decreasing the photosynthesis capacity and leading to significant losses in yield. The coffee berry borer, H. hampei, is the most damaging insect pest of coffee worldwide. This pest lives inside the coffee berry consuming the seeds thus reducing the quantity and quality of the coffee grains. The most common method of control to both pests is the use of synthetic pesticides, which have a low effectiveness due to the selection of resistant populations. Additionally, the excessive use of these products could have a severe impact in the environment and non-target individuals. An alternative for the management of these pests could be the use of specific plants and their secondary metabolites, such as the essential oils. Varronia curassavica is a medicinal species that produces an essential oil with a range of biological activities besides attracting natural enemies, such as the Chrysopidae. The specie Chrysoperla externa is an important biological control agent of a variety of pests, including L. coffeella and H. hampei. In this study, I investigate whether V. curassavica can be used in the management of L. coffeella and H. hampei and benefit their natural enemy C. externa. I performed a greenhouse experiment to evaluate if the association of V. curassavica plants with coffee plants would affect the oviposition of L. coffeella and its predator C. externa (Chapter I). The association of the V. curassavica plants with coffee plants didn’t affect L. coffeella oviposition, however, it increased the C. externa oviposition. I also investigate the effects of the V. curassavica essential oil in the oviposition and the development of eggs and mines of L. coffeella (Chapter II). The V. curassavica essential oil inhibited the oviposition of L. coffeella but did not affect the development of its eggs and mines. I evaluated the lethal and sublethal effects of V. curassavica essential oil on H. hampei, assessing the mortality rates, the mobility of H. hampei, and the repellence of the essential oil to this pest (Chapter III). The essential oil of V. curassavica is toxic to H. hampei and affects its mobility, but it wasn’t repellent to the pest in the concentration tested. This study demonstrates that V. curassavica plant and its essential oil could be a safer alternative in the management of the key coffee pests. Keywords: Coffea sp. Leucoptera coffeella. Hypothenemus hampei. Chrysoperla externa.

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Section: Discussionsupporting

confidence: 46%

Varronia curassavica Jacq. (Boraginaceae) as an agroecological tool for coffee pest management

Andrade

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“…O estudo com óleo essencial do alecrim (Rosmarinus officinalis) torna-se relevante devido suas propriedades farmacológicas como atividade antioxidante, anti-inflamatória e com efeito terapêutico sobre os sintomas deletérios causados pelo mal de Alzheimer, na inibição da acetilcolinesterase (Souza et al, 2012;Tiuzzi & Furlan, 2016). A investigação sobre o óleo volátil de alecrim contribui para o conhecimento das características farmacológicas e etnobotânica do vegetal, devido à diversidade de constituintes químicos de uso fitoterapêutico, como também discutido por Porte e Godoy (2001), Ribeiro (2011), Lee et al (2020).…”

Section: Introductionunclassified

The use of Rosmarinus officinalis L. essential oil in Alzheimer's patients

Dias¹,

Filho

Porfiro³

2022

Braz. J. of Sci.

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text Rosmarinus officinalis is a species of the Lamiaceae family and is popularly known in Brazil as "field rosemary, golden rosemary, rosemary". The species is aromatic due to the presence of essential oil, a complex class of monoterpenes, sesquiterpenes and phenylpropanoids that are found in the aerial parts of the plant. Thus, the interest of studies on volatile compounds and their possible biological actions, mainly on pathological processes, are a subject of study. The use of essential oils in pharmacology and aromatherapy is remarkable. And R. officinalis essential oil is famous for its volatile compounds used in acetylcholinesterase inhibition models. The aim of the study was to review in the literature the use of R. officinalis oil and its use in Alzheimer's disease phytotherapy. A survey of studies (articles, dissertations and theses) on the use of rosemary essential oil on acetylcholinesterase inhibition was carried out. As a result, it was observed that the use of R. officinalis essential oil presents a significant amount of studies with excellent results of inhibiting this enzyme on Alzheimer's disease and on improving cognition and memory, mainly in models induced by scopolamine dementia. It is noted that still, little is known about the use of rosemary essential oil, this study being a review of the main biological uses, however, there is still much to research. Rosmarinus officinalis oil may be a new pharmacological prototype due to its volatile compounds with great aptitude in the treatment of pathologies such as Alzheimer's disease.

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“…O óleo essencial de alecrim (Rosmarinus offininalis L) pode ser utilizado na prevenção do Alzheimer em decorrência da sua composição química, especialmente compostos terpênicos, que possuem a capacidade de estimular o sistema nervoso central e consequentemente auxiliar em melhorias ao sistema cognitivo (PORTE;GODOY, 2001). Esses compostos atuam pela sua ação antioxidante ou pela inibição da acetilcolinesterase (AChE), que retarda a hidrólise catabólica da acetilcolina com o intuito de compensar a escassez da mesma nos terminas sinápticos (OBULESU;RAO, 2011;SOUZA et al, 2012). Desta forma, esse trabalho teve o objetivo de extrair e determinar a atividade antioxidante do óleo essencial de alecrim (Rosmarinus officinalis L.).2 METODOLOGIAForam selecionadas plantas adultas da espécie de Salvia rosmarinus comumente conhecidos como alecrim, provenientes da cidade de Cândido Mota.Após a coleta foram selecionadas as folhas frescas para o os procedimentos experimentais.Para a extração foram utilizadas 50g do material botânico em 500 mL de água destilada submetidos a hidrodestilação em destilador do tipo Clevenger (figura 1), sob a temperatura de 150ºC por três horas.…”

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Estudo Da Atividade Antioxidante Do Óleo Essencial De Alecrim (Rosmarinus Officinalis L) No Tratamento Ao Estresse Oxidativo Na Doença De Alzheimer

Oliveira¹,

Faria²,

Amorim³

2022

SES

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O óleo essencial de alecrim (Rosmarinus offininalis L) pode ser utilizado na prevenção do Alzheimer em decorrência da sua composição química, especialmente compostos terpênicos que atuam pela sua ação antioxidante ou pela inibição da acetilcolinesterase (AChE), que retarda a hidrólise catabólica da acetilcolina com o intuito de compensar a escassez da mesma nos terminas sinápticos. Esse trabalho teve o objetivo de extrair e determinar a atividade antioxidante do óleo essencial de alecrim. Primeiramente extraiu-se o óleo essencial do material botânico de alecrim por hidrodestilação em destilador do tipo Clevenger. A determinação da capacidade antioxidante foi realizada em triplicata pelo método de radical livre utilizando o reagente 2,2-difenil-1-picril hidrazil (DPPH). O rendimento obtido na extração do óleo essencial de alecrim foi de 0,42%. O resultado obtido para a atividade antioxidante do óleo essencial de alecrim foi satisfatório, sendo a capacidade de redução de DPPH em 30 minutos de 87,21%±0,25. Os resultados obtidos indicam que o óleo essencial de alecrim pode ser utilizado no tratamento da doença de Alzheimer, visto que o mesmo pode atuar inibindo o stress oxidativo, a principal causa para o desenvolvimento de doenças neurodegenerativas. Deve-se considerar, entretanto, a composição do óleo essencial visto que os fatores ambientais e de cultivo podem influenciar na capacidade antioxidante do mesmo. Rosemary essential oil (Rosmarinus offininalis L) can be used in the prevention of Alzheimer's due to its chemical composition, especially terpenic compounds that act by its antioxidant action or by the inhibition of acetylcholinesterase (AChE), which delays the catabolic hydrolysis of acetylcholine in order to compensate the lack of it in the synaptic terminals. This work aimed to extract and determine the antioxidant activity of rosemary essential oil. First, the essential oil was extracted from the rosemary botanical material by hydrodistillation in a Clevenger distiller. The antioxidant capacity was determined in triplicate by the free radical method using the reagent 2,2-diphenyl-1-picryl hydrazyl (DPPH). The yield obtained from the extraction of rosemary essential oil was 0.42%. The result obtained for the antioxidant activity of rosemary essential oil was satisfactory, and the DPPH reduction capacity in 30 minutes was 87.21%±0.25. The results obtained indicate that rosemary essential oil can be used in the treatment of Alzheimer's disease, since it can act by inhibiting oxidative stress, the main cause for the development of neurodegenerative diseases. However, the composition of the essential oil should be considered, since environmental and cultivation factors can influence its antioxidant capacity.

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Óleos essenciais como inibidores da acetilcolinesterase

Cited by 7 publications

References 34 publications

Varronia curassavica Jacq. (Boraginaceae) as an agroecological tool for coffee pest management

Varronia curassavica Jacq. (Boraginaceae) as an agroecological tool for coffee pest management

The use of Rosmarinus officinalis L. essential oil in Alzheimer's patients

Estudo Da Atividade Antioxidante Do Óleo Essencial De Alecrim (Rosmarinus Officinalis L) No Tratamento Ao Estresse Oxidativo Na Doença De Alzheimer

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