Oleanane-Type Triterpenoids from the Leaves and Twigs of Fatsia polycarpa

Abstract

Seven new oleanane-type triterpenoids (1-7), named fatsicarpains A-G, and the known compounds 3α-hydroxyolean-11,13(18)-dien-28-oic acid (8) and 3α-hydroxyolean-11-en-28,13β-olide (9) were isolated from the leaves and twigs of Fatsia polycarpa on the basis of bioassay-guided fractionation. The structures of compounds 1-7 were elucidated through spectroscopic analyses and single-crystal X-ray crystallography of 1, 8, and 9. Cytotoxicity against HepG2 2.2.15 and AGS cells and antihepatitis B virus (HBV) and antibacterial activities of 1-9 were also evaluated in vitro.

A new triterpene and protective effect ofPeriploca somaliensisBrowicz fruits against CCl4-induced injury on human hepatoma cell line (Huh7)

“…The 1 H NMR spectrum of compound 3 displayed signals due to seven tertiary methyl groups at d H 1.10 (H-27), 1.06 (H-25), 1.05 (H-26), 0.99 (H-23 and 29), 0.92 (H-30) and 0.80 ppm (H-24). This indicated an oleanane structure of compound 3, which was confirmed by comparing the spectral data with those of related compounds (Cheng et al 2011;Lai et al 2012). 1 H NMR and 13 C NMR spectral data of compound 3 showed the absence of the olefinic bond signals and the appearance of a broad singlet at d H 3.03 ppm integrated for two protons and their corresponding carbon atoms, according to HSQC, displayed at d C 52.7 and 57.3 ppm ascribable for 11a,12a an epoxy group (Xue et al 2011).…”

“…The olefinic bond at C-11/C-12 was evident from the long-range correlations between each of H-11/C-10, C-8, and C-13, and H-12/C-9, C-13, and C-14 in the HMBC spectrum. From the aforementioned discussion and by comparison with the spectral data of the related compounds (Pereda-Miranda & Delgado 1990;Cheng et al 2011;Huang et al 2012), compound 2 could be identified as 3b-hydroxy-urs-11-en-13b,28-olide which is a newly isolated compound.…”

Anti-Inflammatory Effects and Mechanisms ofFatsia polycarpaHayata and Its Constituents

“…There are three species in the genus of Fatsia (belonging to the Araliaceae family), that is, Fatsia polycarpa Hayata, an evergreen shrub endemic to Taiwan, Fatsia japonica, and Fatsia oligocarpela , originated from Japan and Bonin Islands, respectively [1]. F. japonica and F. polycarpa have been used as an herbal medicine in Japan and in Taiwan in treating diseases, such as coughing, ankylosing spondylitis, osteoarthritis, rheumatism, rheumatoid arthritis and tendinitis, and in blood circulation improvement [1, 2].…”

“…F. japonica and F. polycarpa have been used as an herbal medicine in Japan and in Taiwan in treating diseases, such as coughing, ankylosing spondylitis, osteoarthritis, rheumatism, rheumatoid arthritis and tendinitis, and in blood circulation improvement [1, 2]. Nonetheless, the therapeutic activity of F. polycarpa has seldom been scientifically investigated and the bioactive constituents from these plants are not clear.…”

“…The constituents in the methanolic extract of leaves and twigs of Fatsia polycarpa were previously characterized [1]. The extract was rich in phytosterols in which brassicasterol was a major one (unpublished data).…”