Olea europea L. Leaves and Hibiscus sabdariffa L. Petals Extracts: Herbal Mix from Cardiovascular Network Target to Gut Motility Dysfunction Application

Abstract

It is well known that diet and nutrition play a critical role in the etiopathogenesis of many disorders. On the other hand, nutrients or bioactive compounds can specifically target and control various aspects of the mechanism underlying the pathology itself, and, in this context, diseases related to intestinal motility disorders stand out. The Herbal Mix (HM) consisting of Olea europea L. leaf (OEE) and Hibiscus sabdariffa L. (HSE) extracts (13:2) has been proven to be a promising nutraceutical option for many diseases, but its potential in inflammatory-driven gastrointestinal disorders is still unexplored. In this study, HM effects on guinea-pig ileum and colon contractility (induced or spontaneous) and on human iNOS activity, as well as on human colorectal adenocarcinoma Caco-2 cells, were studied. Results showed that the HM can control the ileum and colon contractility without blocking the progression of the food bolus, can selectively inhibit iNOS and possesses a strong pro-apoptotic activity towards Caco-2 cells. In conclusion, the present results suggest that, in some diseases, such as those related to motility disorders, an appropriate nutritional approach can be accompanied by a correct use of nutraceuticals that could help not only in ameliorating the symptoms but also in preventing more severe, cancer-related conditions.

Tannins-Based Extracts: Effects on Gut Chicken Spontaneous Contractility

“…At the end of each single concentration, a 5-min stationary period was selected, and, for each interval, the following parameters were evaluated: mean contraction amplitude (MCA) calculated as the mean force value (g); the force contraction standard deviations, considered as an index of the spontaneous contraction variability (SCV); and basal spontaneous motor activity (BSMA), calculated as the percentage (%) variation of each mean force value (g) with respect to the control. The spontaneous contraction rates were investigated through a standard FFT analysis, and the evaluation of the absolute powers (inside a Power Spectral Density plot) of the following frequency bands of interest: low [0.0, 0.2] Hz, medium [0.2, 0.6] Hz and high [0.6, 1.0] Hz [ 43 ].…”

Magnolia officinalis L. bark extract and respiratory diseases: From traditional Chinese medicine to western medicine via network target

“…Spontaneous contractility was studied as previously described (Mattioli et al, 2022). Briefly, for the trachea and lung, the tracing graphs of spontaneous contractions (SCs) were continuously recorded with LabChart Software (ADInstruments, Bella Vista, NSW, Australia).…”

“…In view of a multiple targeting activity and to advance the understanding of the best use of M . officinalis as possible dietary supplement, the aim of the study was to investigate the effects of different bark extracts as well as those of the reference compounds honokiol and magnolol, on some targets connected to airway pathologies (antibacterial and lung and trachea relaxing activity), in line with the network target approach for the application of phytocomplexes as food supplement in a perspective of an integrated therapy (Mattioli et al, 2022).…”

A potential host and virus targeting tool against COVID-19: Chemical characterization, antiviral, cytoprotective, antioxidant, respiratory smooth muscle relaxant effects of Paulownia tomentosa Steud

“…The experimental design was previously described [39] . Briefly, for the trachea and lung the tracing graphs of spontaneous contractions were continuously recorded with the LabChart Software (ADInstruments, Bella Vista, New South Wales, Australia).…”