A potential host and virus targeting tool against COVID-19: Chemical characterization, antiviral, cytoprotective, antioxidant, respiratory smooth muscle relaxant effects of Paulownia tomentosa Steud

Magurano, Fabio; Micucci, Matteo; Nuzzo, Domenico; Baggieri, Melissa; Picone, Pasquale; Gioacchini, Silvia; Fioravanti, Raoul; Bucci, Paola; Kojouri, Maedeh; Mari, Michele; Retini, Michele; Budriesi, Roberta; Mattioli, Laura; Corazza, Ivan; Liberto, Valentina Di; Todaro, Luigi; Giuseppetti, Roberto; D’Ugo, Emilio; Marchi, Antonella; Mecca, Marisabel; D’Auria, Maurizio

doi:10.1016/j.biopha.2022.114083

Cited by 4 publications

(1 citation statement)

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“…The potentiality of sesamin as a compound to inhibit the infection of live SARS-CoV-2 is an exciting development in the fight against the virus [9]. Sesamin, as a major compound in the Paulownia tomentosa, is a naturally occurring compound found in sesame seeds and has been recently reported to possess potent antiviral activity against SARS-CoV-2 in vitro [27,28]. Studies have shown that sesamin is able to bind to the spike protein of the virus, preventing it from entering the host cell.…”

Section: Antioxidants In Attenuating Covid-19 Symptomsmentioning

confidence: 99%

Pharmacogenomic Landscape of Ivermectin and Selective Antioxidants: Exploring Gene Interplay in the Context of Long COVID

Yang,

Singh

2023

IJMS

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COVID-19 pandemic has caused widespread panic and fear among the global population. As such, repurposing drugs are being used as viable therapeutic options due to the limited effective treatments for Long COVID symptoms. Ivermectin is one of the emerging repurposed drugs that has been shown effective to have antiviral effects in clinical trials. In addition, antioxidant compounds are also gaining attention due to their capabilities of reducing inflammation and severity of symptoms. Due to the absence of knowledge in pharmacogenomics and modes of actions in the human body for these compounds, this study aims to provide a pharmacogenomic profile for the combination of ivermectin and six selected antioxidants (epigallocatechin gallate (EGCG), curcumin, sesamin, anthocyanins, quercetin, and N-acetylcysteine (NAC)) as potentially effective regimens for long COVID symptoms. Results showed that there were 12 interacting genes found among the ivermectin, 6 antioxidants, and COVID-19. For network pharmacology, the 12 common interacting genes/proteins had the highest associations with Pertussis pathway, AGE-RAGE signaling pathway in diabetic complications, and colorectal cancer in the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Disease analyses also revealed that the top three relevant diseases with COVID-19 infections were diabetes mellitus, ischemia, reperfusion injury. We also identified 6 potential target microRNAs (miRNAs) of the 12 commonly curated genes used as molecular biomarkers for COVID-19 treatments. The established pharmacogenomic network, disease analyses, and identified miRNAs could facilitate developments of effective regimens for chronic sequelae of COVID-19 especially in this post-pandemic era. However, further studies and clinical trials are needed to substantiate the effectiveness and dosages for COVID-19 treatments.

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Section: Antioxidants In Attenuating Covid-19 Symptomsmentioning

confidence: 99%