Olanzapine and acute urinary retention in two geriatric patients

Acute Abdominal Pain Accompanied by High Creatinine in a Female Patient With Schizophrenia

“…However, varying degrees of blockade are also caused at dopamine, histaminic, and adrenergic receptors (promote urinary retention). 8 Benzodiazepines, such as lorazepam and diazepam, can provoke urinary retention likely because of muscle relaxation. 6 13 Indwelling urethral and suprapubic catheter 4 Eosinophilic cystitis 14 Pelvic organ prolapse Alcohol intoxication 3,4 and in combination with substance abuse Opioid 15 and benzodiazepine overdose 16 Cases of traumatic or iatrogenic rupture were not included in this overview.…”

Expanding our Understanding of Atypical Antipsychotics: Acute Urinary Retention Secondary to Olanzapine

“…Of the atypical antipsychotics, olanzapine and clozapine have been shown to have the greatest antimuscarinic effects leading to more reported anticholinergic effects than others within the class [ 21 ]. Cohen et al reported acute urinary retention in two elderly patients after being started on olanzapine for psychiatric conditions in The American Journal of Geriatric Pharmacology [ 22 ]. While the patients had multiple factors that could lead to urinary retention (i.e., BPH and age), it was not until they had started low dose olanzapine did acute urinary retention with acute kidney injury develop [ 22 ].…”

“…Cohen et al reported acute urinary retention in two elderly patients after being started on olanzapine for psychiatric conditions in The American Journal of Geriatric Pharmacology [ 22 ]. While the patients had multiple factors that could lead to urinary retention (i.e., BPH and age), it was not until they had started low dose olanzapine did acute urinary retention with acute kidney injury develop [ 22 ]. In a second case report, a 30-year-old female developed acute urinary retention after starting olanzapine for atypical psychosis that resolved once the medication was discontinued and the patient was changed to aripiprazole [ 23 ].…”

The management of voiding dysfunction in persons with dementia

“…The anticholinergic side effects, as well as the functional side effects of oversedation, must be closely monitored by the clinician. Case reports have also hinted at a possible risk of acute urinary retention among antipsychotics that have significant antimuscarinic activity such as olanzapine [19].…”