Olanexidine gluconate formulations as environmental disinfectants for enveloped viruses infection control

Imai, Kazutami; Hagi, Akifumi; Yamagawa, Sachi; Sano, Daisuke

doi:10.1016/j.jhin.2021.03.014

Cited by 4 publications

(5 citation statements)

References 6 publications

(7 reference statements)

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“…Nine studies validated the spectrum: seven for bacteria and fungi 20 , 21 , 22 , 23 , 24 , 25 , 28 and four for viruses. 28 , 32 , 33 , 34 Several studies 20 , 23 , 25 , 28 used the minimum bactericidal concentration (MBC) at which bacterial growth did not occur as an indicator of the bactericidal effect of skin disinfectants.…”

Section: Resultsmentioning

confidence: 99%

“…Imai et al. 34 also reported on the potential usage of OLG formulations as environmental disinfectants for the control of infections by enveloped viruses (influenza A [H1N1], human coronavirus, feline infectious peritonitis virus, human herpesvirus, and respiratory syncytial virus).…”

Section: Resultsmentioning

confidence: 99%

“…The OLG hand rub had the highest antiviral effect, when compared to other agents (ethanol [pH 7], ethanol‐A [pH 3], and OLG), suggesting its potential for use as a hand sanitizer (Table 2). Imai et al 34 . also reported on the potential usage of OLG formulations as environmental disinfectants for the control of infections by enveloped viruses (influenza A [H1N1], human coronavirus, feline infectious peritonitis virus, human herpesvirus, and respiratory syncytial virus).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Shinzato

Sakihara

Kishihara

et al. 2022

Acute Medicine & Surgery

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Surgical site infections (SSIs) and catheter‐related bloodstream infections (CRBSIs) caused by bacteria from surfaces poorly disinfected with chlorhexidine gluconate (CHG) and povidone‐iodine (PVP‐I) are increasing. Olanexidine gluconate (OLG) was developed in 2015 in Japan to prevent SSI and CRBSI caused by bacteria resistant to CHG and PVP‐I. This scoping review aimed to identify the knowledge gap between what is known and what is not known about the disinfection efficacy of OLG. We searched MEDLINE through PubMed, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the International Clinical Trials Registry Platform search database, ClinicalTrials.gov , and the Web‐based database of Japanese medical articles for works published to July 18, 2021. Manual reference searches were also carried out. A total of 131 studies were screened. Forty‐seven studies were included in this review and classified into two major categories: studies on pharmacological effects and spectrum ( n = 29) and studies on clinical and adverse effects ( n = 18). Olanexidine gluconate showed bactericidal activity against methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci, in addition to common Gram‐positive and Gram‐negative bacteria. In clinical settings, although there is limited evidence on SSI prevention, 1.5% OLG might be more effective than 10% PVP‐I and 1% CHG in preventing SSI. However, the clinical usefulness of OLG is unclear due to the limited number of clinical studies. Also, clinical research is limited to studies targeting SSI prevention, and there are no clinical studies on CRBSI. Further clinical studies are needed on SSI and CRBSI prevention.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Shinzato

Sakihara

Kishihara

et al. 2022

Acute Medicine & Surgery

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“…In clinical trials, Obara et al reported that 1.5% OLG significantly reduced the occurrence of overall surgical site infections (SSIs) and superficial SSIs compared with PVP-I in cleancontaminated surgery 2 . Additionally, the findings of previous studies showed that 1.5% olanexidine-containing 70% ethanol formulation for hand hygiene (OLG hand rub; OLG-HR) was more virucidal than ethanol against human noroviruses 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Disinfection efficacy and mechanism of olanexidine gluconate against norovirus

Imai

Tanaka

Miyoshi

et al. 2022

American Journal of Infection Control

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Olanedine antiseptic solution efficacy was evaluated in a randomized, controlled clinical trial in Japan, and surgical site infections following gastrointestinal surgery occurred less frequently with its use than with the use of commercial antiseptics povidone-iodine and chlorhexidine ( 15 , 17 , 18 ). Its bactericidal efficacy as a topical antiseptic led to its proposed use for preoperative skin preparation prior to surgery ( 15 ) and as an environmental disinfectant for the prevention of nosocomial transmission of enveloped viruses, including influenza A viruses, respiratory syncytial viruses, and coronaviruses ( 19 ). Here, we tested the effectiveness, and explored the mechanism of action of olanexidine gluconate-containing hand rub (OLG-HR) on HuNoV infectivity.…”

Section: Introductionmentioning

confidence: 99%