Okra (Hibiscus esculentus) gum-alginate blend mucoadhesive beads for controlled glibenclamide release

Sinha, Priyanka; Ubaidulla, Udhumansha; Nayak, Amit Kumar

doi:10.1016/j.ijbiomac.2014.10.002

Cited by 114 publications

(36 citation statements)

References 37 publications

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“…These plant polysaccharides have been used as potential pharmaceutical excipients in tablets, capsules, matrix-controlled systems, microparticles, nanoparticles, ophthalmic preparations, gels, creams, emulsions, suspensions, etc. [13,14]. Thus, with the increasing demand for plant polysaccharides, it is necessary to explore newer sources to meet their huge industrial demands [15].…”

Section: Introductionmentioning

confidence: 99%

Screening of polysaccharides from tamarind, fenugreek and jackfruit seeds as pharmaceutical excipients

Nayak

Pal

Santra

2015

International Journal of Biological Macromolecules

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108

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Section: Introductionmentioning

confidence: 99%

Screening of polysaccharides from tamarind, fenugreek and jackfruit seeds as pharmaceutical excipients

Nayak

Pal

Santra

2015

International Journal of Biological Macromolecules

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108

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“…OFG contains D-galactose, L-rhamnose, and L-galacturonic acid [8,9]. The main structural elements of okra polysaccharide were described by Tomada, Shimada, Saito, and Sugi (1980) who concluded that it contained a repeating unit of alternating α-(1-2)-linked rhamnosyl and α-(1-4)-linked galacturonic acid residues with a disaccharide side chain of β-(1-4)-linked galactosyl moieties attached to O-4 of about half the L-rhamnosyl residues [10] and degree of acetylation up to 58 (DA = 58) [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…A gastroprotective effect of the methanolic extract of okra in ethanol-induced gastric ulcer in rats was reported [15,16]. OFG is inexpensive, consistent in quality, chemically inert, biodegradable, biocompatible in nature, and reliable in supply [8,17]. These attributes of OKG lead to usefulness as excipients in the development of various pharmaceutical formulations [2,8,[17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Extraction of Gum From Abelmoschus Esculentus: Physicochemical Peculiarity and Antioxidant Prepatent

Nagpal

Aggarwal

Jain

et al. 2017

Asian J Pharm Clin Res

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Objective: This study is aimed to extract gum from Abelmoschus esculentus using ultrasonic assisted method and exploring physicochemical, functional, and antioxidant potential of gum for food and pharmaceuticals. Materials and Methods:The extraction of gum from okra was done employing ultrasound-assisted method to improvise the yield. The extracted gum was further characterized for physical properties including swelling index, solubility, water sorption time, packing and flow properties, electrical properties, zeta potential, scanning electron microscopy, and antioxidant activity. Results:The extraction yield of okra fruit gum (OFG) was found to be 31.52%±0.22% (n=3). The OFG powder obtained after lyophilization showed good flow properties as determined from the results of angle of repose (34.21°), Hausner ratio (1.14), and % compressibility (12.5%). An increase in solubility and swelling index of OFG with increase in pH of buffer from 2.0 to 7.4 was observed. The freeze dried OFG possess rough surface and zeta potential of −9.85 mV. Application of derivatized/interacted OFG gum for modification of drug release profiles is concluded from high degree of esterification of 7.8. Conclusion:The result suggest that the antioxidant activity of OFG was higher compared to corn flour gum. Thus, OFG could be utilized as natural antioxidant food ingredients and also for application in medicine and health-care products.

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“…As a result of this, the drug is slowly released at a desired rate which results in an enhanced gastric retention time as well as a better control of the fluctuation in plasma drug concentration and thus, increases the bioavailability. Currently, floatation and bioadhesion approaches are being extensively examined to improve therapeutic efficacy by maximizing bioavailability through gastro retention of the dosage form [19][20][21][22][23][24][25][26][27][28][29]. Recent years, the combination of floatation and bioadhesion approaches has gained importance in the development of gastro retentive drug delivery system [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Floating-Bioadhesive Matrix Tablets of Hydralazine HCL Made of Cashew Gum and HPMC K4m

Hasnain

Rishishwar

Ali

2017

Int J Pharm Pharm Sci

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Objective: The objective of this paper was to prepare and evaluate floating-bioadhesive cashew gum-hydroxypropyl methylcellulose (HPMC K4M) matrix tablets for the gastro-retentive release of hydralazine HCl. Methods:The cashew gum-HPMC K4M matrix tablets of hydralazine HCl were prepared by direct compression method with the incorporation of sodium bicarbonate and citric acid as effervescent agents. Drug contents, weight variations, hardness, friability, in vitro swelling, in vitro floatation, ex vivo mucoadhesion and in vitro drug release of these matrix tablets were evaluated.Results: Drug contents, weight variations, hardness and friability of these matrix tablets were within the compendia limits. These tablets were floated well in vitro over 12 h in simulated gastric fluid (SGF, pH 1.2) with minimum lag time. The ex vivo adhesion of these matrix tablets with goat intestinal mucosa exhibited good bioadhesion in a wash off test. All these cashew gum-HPMC K4M floating-bioadhesive matrix tablets of hydralazine HCl showed in vitro sustained releases of hydralazine HCl over 12 h in SGF, pH 1.2. The in vitro hydralazine HCl followed Korsmeyer-Peppas kinetic model and anomalous (non-Fickian) diffusion mechanism. The drug-polymer compatibility analysis by FTIR spectroscopy indicated the absence of any drug-polymer interaction within this cashew gum-HPMC K4M floating-bioadhesive matrix tablets of hydralazine HCl. Conclusion:The results clearly indicate a promising potential of the use of cashew gum as matrix forming a material with HPMC K4M to prepare matrix tablets for gastro retentive delivery of hydralazine HCl through the combined approach of floatation and bioadhesion to reduce the dosing rate with better patient compliances.

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Okra (Hibiscus esculentus) gum-alginate blend mucoadhesive beads for controlled glibenclamide release

Cited by 114 publications

References 37 publications

Screening of polysaccharides from tamarind, fenugreek and jackfruit seeds as pharmaceutical excipients

Screening of polysaccharides from tamarind, fenugreek and jackfruit seeds as pharmaceutical excipients

Extraction of Gum From Abelmoschus Esculentus: Physicochemical Peculiarity and Antioxidant Prepatent

Floating-Bioadhesive Matrix Tablets of Hydralazine HCL Made of Cashew Gum and HPMC K4m

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