Oil-in-water lipid emulsions: implications for parenteral and ocular delivering systems

Shunmugaperumal, Tamilvanan

doi:10.1016/j.plipres.2004.09.001

Cited by 129 publications

(67 citation statements)

References 210 publications

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“…In fact, nanosystems are designed to present a reduced size so that after intravenous administration they can evade more easily the reticuloendothelial system and reach the target efficiently. 23,24 Nanosystems displaying negative zeta potentials are likewise important because they exhibit reduced particle agglomeration effects and provide higher physical stability to the formulation. 25 In order to quantify BZN incorporated in the nanosystems, a new chromatographic method was proposed and validated.…”

Section: Resultsmentioning

confidence: 99%

Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid Formulations

Almeida¹,

Marcial²,

Gouveia³

et al. 2016

Journal of the Brazilian Chemical Society

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Benznidazole (BNZ) has been employed in the treatment of Chagas disease; however, its low water solubility is a drawback, which can be overcome by incorporating BZN within nanostructured systems. The aim of this work was to validate a chromatographic method for determination of BZN incorporated in nanoemulsions (NE) and nanostructured lipid carriers (NLC). The method was validated according to the International Conference on Harmonization guidelines. No interferences from the excipients of both systems on the BZN peak were observed. Linearity presented a correlation coefficient higher than 0.99 in the range of 5.0-30.0 µg mL -1 . Relative standard deviation values for intra-and inter-days precision were lower than 2% and mean recovery ranged from 93.6 to 105.7%. BZN-loaded nanocarriers exhibited physico-chemical characteristics acceptable for parenteral administration and the encapsulation efficiency was almost 100% for both systems. The method shows a good potential to be employed in the determination of BZN in lipid nanostructures.

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Section: Resultsmentioning

confidence: 99%

Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid Formulations

Almeida¹,

Marcial²,

Gouveia³

et al. 2016

Journal of the Brazilian Chemical Society

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“…As it was reported in the drug delivery system with lipid emulsions, the emulsion can be recognized as artificial chylomicrons. 52 Because the LCNPs melt at body temperature, it can also be recognized as artificial chylomicrons which enable the specific accumulation into the liver. Furthermore, in the body distribution study, the concentration in the spleen with the LCNP formulation is not significantly different from that with the HGC formulation, while the difference in the liver is significant, as shown in Figure 10A.…”

Section: Discussionmentioning

confidence: 99%

Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Lee¹,

Park²,

Bae³

et al. 2016

IJN

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Liquid crystal nanoparticles have been utilized as an efficient tool for drug delivery with enhanced bioavailability, drug stability, and targeted drug delivery. However, the high energy requirements and the high cost of the liquid crystal preparation have been obstacles to their widespread use in the pharmaceutical industry. In this study, we prepared liquid crystal nanoparticles using a phase-inversion temperature method, which is a uniquely low energy process. Particles prepared with the above method were estimated to be ~100 nm in size and exhibited a lamellar liquid crystal structure with orthorhombic lateral packing. Pharmacokinetic and tissue distribution studies of a hydrophobic peptide-based drug candidate formulated with the liquid crystal nanoparticles showed a five-fold enhancement of bioavailability, sustained release, and liver-specific drug delivery compared to a host–guest complex formulation.

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“…Thus, for a certain period of time, the oral cavity becomes a CHG reservoir, which prolongs its chemical activity in preparations [22]. The ocular surface (cornea and conjunctiva) is also negatively charged [23,24], and the paracellular space is more permeable to cations than to anions at physiological pH [25,26] consistently the ocular surface may also become a CHG reservoir, which prolongs its chemical activity in preparations. This phenomenon depathogenizes the ocular surface flora intraoperatively and postoperatively but bacteriological culture from the ocular surface may continue to be positive.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Assay of Chlorhexidine-Wetted Textile Napkins for Surgical Site Disinfection in Ocular Surgery

Eslami¹

2013

IJCM

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Background: As a new intraoperative disinfection method, chlorhexidine-wetted textile napkins have been employed in order to cover the upper and lower eyelid edges, eyelid skin, eyelashes, lid margins and palpebral conjunctiva during phacoemulsification cataract extraction. This study was conducted to compare the antimicrobial activity of textile napkins before and after their use. Methods: This study evaluated 80 textile napkins wetted with 0.02% aqueous solution of chlorhexidine. All textile napkins were divided into groups. The study group consisted of 60 used textile napkins which were collected from 29 patients (30 eyes) at the end of phacoemulsification, and the control group included 20 unused sterile textile napkins. Antimicrobial assay was performed by means of measuring the growth inhibition zones of the standard or clinical isolate strains under the textile napkins on the surface of agar media. Results: The number of textile napkins and the diameter of the growth inhibition zones (mm) in the study group and in the control group relating to gram-positive, gram-negative, and fungi were: 24/31 vs. 8/31, 32/30 vs. 8/30, and 4/30 vs. 4/30. The diameter of the growth inhibition zones of gram-positive bacteria was more than other investigated microorganisms. In the growth inhibition zones, exogenous microorganism colonies were not found. Conclusion: Antimicrobial activity of textile napkins wetted with 0.02% aqueous solution of chlorhexidine against gram-positive bacteria is more than gram-negative bacteria and fungi, and is preserved to the end of the phacoemulsification.

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Oil-in-water lipid emulsions: implications for parenteral and ocular delivering systems

Cited by 129 publications

References 210 publications

Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid Formulations

Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid Formulations

Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Antimicrobial Assay of Chlorhexidine-Wetted Textile Napkins for Surgical Site Disinfection in Ocular Surgery

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