Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.

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The synthesis of conjugated polymers using magnetically recyclable Pd‐Fe3O4 heterodimer nanocrystals (HNCs) is reported. The consistent high catalytic activity of the HNCs affords various conjugated polymers with high molecular weights in excellent yields. The Pd‐Fe3O4 HNCs can be easily recovered from the reaction mixture using an external magnet and reused up to 11 times in the polymerization. This method takes one step closer toward the green synthesis of conjugated polymers.