Oil-in-water lecithin-based microemulsions as a potential delivery system for amphotericin B

Effects of Oil and Drug Concentrations on Droplets Size of Palm Oil Esters (POEs) Nanoemulsion

“…All of the nanoemulsion formulated had the droplet size in nano-range. Similar effects of oil with droplets size were observed by other researchers 9 .…”

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

“…In previous studies with microemulsions containing the antitumor drug doxorubicin, we observed similar results, with drug loading increasing the droplet size of the microemulsions [16]. The same effect was also observed for amphotericin B loaded oil-in-water microemulsions [17]. Thus, PYT is a liquid immiscible with water and, as observed with amphotericin B, its solubilization into oil phase contributes to increased droplet size.…”

Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations

“…For example, oral micro-emulsion formulations have been successfully developed for cyclosporine, a highly lipophilic and poorly aqueous soluble drug in order to improve its oral absorption and reduce variations in its absorption (Kim et al, 1997;Cooney et al, 1998). The potential of liposomes and micro-emulsions as drug delivery carriers for the treatment of various topical and systemic fungal infections with several antifungal drugs such as amphotericin B, fluconazole, miconazole and griseofulvin has been proved in the literature (Peira et al, 2008;Pestana et al, 2008;Bachhav & Patravale, 2009;Monforte et al, 2010;Sheikh et al, 2010;Aggarwal & Goindi, 2012;Fauvel et al, 2012;Aggarwal et al, 2013). Topical liposomes and micro-emulsions offered several advantages as drug delivery vehicles such as enhanced skin permeation, enhanced therapeutic efficacy/bioavailability, avoidance of hepatic first pass metabolism and systemic adverse effects (Bachhav & Patravale, 2009;Sheikh et al, 2010;Aggarwal & Goindi, 2012;Aggarwal et al, 2013).…”